Results Among the 243 patients, we detected a total of 433 pyrin mutations and 22 different sequence variants, including one new mutation (p.Gly488Asp). The four most frequent alterations were p.Met694Val (55%, n=238), p.Met680lle (12%, n=52), p.Val726Ala (10%, n=44) and p.Glu148Gln (8%, n=34). Ethnic origin could be determined in 224 cases; the prevailing ancestry was Turkish (83%, n=185), 8% ...

Methods 6 turkish patients with the clinical diagnosis of FMF exhibiting homocygous or combined heterozygous mutations within the MEFV gene were included. Patients still exhibited clinical symptoms and elevated inflammation markers despite sufficient colchicine therapy (“instable disease”). Healthy probands served as controls. Their health status was assessed by a standardized questionnaire. Al...

Abstract Aim Inguinal hernias (IH) can be repaired via open, laparoscopic, and robotic approaches, with or without mesh. We aim to understand the changing trends in IH repair that may serve as a guideline toward tailored approach for hernia repair. Materials & Methods All patients undergoing primary from 2009–2021 by single surgeon at specialty center were included. Temporal differences eva...

IL22 signaling plays a critical role in the pathogenesis of skin inflammatory diseases such as psoriasis and atopic dermatitis. Smad7 is transforming growth factor β (TGFβ) inhibitor consisting an N-terminal domain, C-terminal linker region harboring PY motif. transgene expression Keratin 5 (K5)+ keratinocytes attenuated K5.TGFβ1 transgene-induced psoriatic inflammation. The downstream mechanis...

INTRODUCTION Nasopharyngeal cancer (NPC) survivors often sustain head-neck-shoulder impairments from conventional treatments, which could disturb sleep. This novel study aimed to examine the efficacy of Tai Chi (TC) Qigong in optimizing temporomandibular joint (TMJ), cervical, and shoulder joint mobility and reducing sleep problems in NPC survivors. METHODS Fifty-two NPC survivors participate...