Background Polymorphisms in genes coding for the neurotrophin, brain-derived neurotrophic factor (BDNF) or its receptors, have been associated with Alzheimer’s disease and related disorders (ADRD), sex-dependent effects. Associations neuropsychiatric symptom (NPS) progression after dementia onset has largely unexplored. In a population-based cohort, we examined relationships between BDNF gene s...

Experience has shown that instructor-led trainings have some advantages that cannot easily be overcome by technology enhanced learning. Direct interaction with an instructor and among the group is often perceived as motivating and more personal. For small groups, in-class trainings can be more cost effective. On-line learning often requires a considerable amount of self-management and progress-...

PURPOSE The National Surgical Adjuvant Breast and Bowel Project B-24 trial, published in June 1999, demonstrated that tamoxifen after breast-conserving surgery (BCS) and radiotherapy for ductal carcinoma in situ (DCIS) reduced the absolute occurrence of ipsilateral and contralateral breast cancer. We assessed the impact of B-24 on practice patterns at selected National Comprehensive Cancer Netw...

Prior to designing a system, customers and contractors should agree on required black box (externally apparent) system behavior. To define this behavior, practical, precise, design independent methods are needed. This paper describes results of a case study’ in which formal event-based approaches are used, demonstrating that a combination of history based traces and guarded event-action stateme...

Report developed under topic #A10AT015, contract W911NF-10-C-0073. Our goal is to provide the technology base for realizing monolithic emitters and optical amplifiers active at 1.5 micron on Si substrates that are compatible with standard processes of the complementary metal-oxide-semiconductor (CMOS) technology. Our approach is to exploit epitaxial growth of III-nitride semiconductors on Si su...

INTRODUCTION TX-004HR is an investigational, applicator-free, vaginal soft gel capsule containing low-dose solubilized 17β-estradiol. The phase 3, randomized, double-blinded, placebo-controlled, multicenter REJOICE trial has shown TX-004HR to be safe and effective for the treatment of moderate to severe dyspareunia in postmenopausal women with vulvar and vaginal atrophy (VVA). AIM To evaluate...

We investigated the influence of pathology data to improve patient outcomes in the treatment of high-grade cervical neoplasia in a joint pathology and gynecology collaboration. Two of us (B.S.D. and M.D.) reviewed all cytology, colposcopy and surgical pathology results, patient history, and pregnancy outcomes from all patients with loop electrosurgical excision procedure specimens for a 33-mont...

Random Amplified Polymorphic DNAs (RAPDs) data were analyzed from eighteen taxa of Cupressus from the eastern hemisphere. The following fourteen taxa were distinct in their RAPDs: Cupressus assamica (India), C. atlantica (Morocco), C. austrotibetica (Tibet), C. cashmeriana (Bhutan), C. chengiana (Sichuan), C. darjeelingensis (India), C. duclouxiana (Yunnan), C. dupreziana (Algeria), C. funebris...