Introduction, and Discussion, and the answers The author certifies that he has no commercial associations (eg, consultancies, stock ownership, equity interest, patent/licensing arrangements, etc) that might pose a conflict of interest in connection with the submitted article. (Adapted with permission of Lippincott Williams and Wilkins from Brand RA. Writing for Clinical Orthopaedics and Related...

A new bit-serial architecture for implementation of high order FIR filters, as well as example FPGA and CMOS realizations are introduced. This structure exploits the simplicity of coefficients which consist of two power-of-two terms to yield efficient implementations. Quantization effects are discussed and a simple block scaling method for reducing rounding and truncation noise in high order fi...

When an addressee is the reference object predicated by a spatial term, does a speaker’s assumption that the reference object is the addressee influence the speaker’s comprehension of spatial terms? This study examined this point by using four Japanese spatial terms. Results indicated that such an assumption biased and changed the boundary defined by the spatial terms and that this bias might b...

OBJECTIVE This phase 3, randomized, double-blind, placebo-controlled study evaluated the efficacy and tolerability of fixed-dose levomilnacipran sustained release (SR) compared with placebo in patients with major depressive disorder (MDD); the study was conducted from September 2009-May 2011. METHOD Outpatients met DSM-IV-TR criteria for MDD with an ongoing major depressive episode ≥ 8 weeks'...

One of the most important problems in modern genomics is to identify which genes are responsible for an specific phenomenon within the cell. This problem can be partially answered by comparing expression data from two sets of related experiments, for instance a set of cancerous and a set of healthy cells, and genes with similar expression level. Unfortunately, the number of genes is usually muc...