Ray, Ramesh M., Barbara J. Zimmerman, Shirley A. McCormack, Tarun B. Patel, and Leonard R. Johnson. Polyamine depletion arrests cell cycle and induces inhibitors p21Waf1/Cip1, p27Kip1, and p53 in IEC-6 cells. Am. J. Physiol. 276 (Cell Physiol. 45): C684–C691, 1999.—The polyamines spermidine and spermine and their precursor putrescine are intimately involved in and are required for cell growth a...

Hardt, Stefan E., Armin Just, Raffi Bekeredjian, Wolfgang Kübler, Hartmut R. Kirchheim, and Helmut F. Kuecherer. Aortic pressure-diameter relationship assessed by intravascular ultrasound: experimental validation in dogs. Am. J. Physiol. 276 (Heart Circ. Physiol. 45): H1078– H1085, 1999.—Intravascular ultrasound (IVUS) has emerged as an important diagnostic method for evaluating vessel diameter...

Marples, David, Jørgen Frøkiaer, and Søren Nielsen. Long-term regulation of aquaporins in the kidney. Am. J. Physiol. 276 (Renal Physiol. 45): F331–F339, 1999.—The discovery of the aquaporin family of water channels has greatly improved our understanding of how water crosses epithelial cells, particularly in the kidney. The study of the mechanisms involved in the regulation of collecting duct w...

Francis, Noelle,Alain Cohen-Solal, and Damien Logeart. Peripheral muscle ergoreceptors and ventilatory response during exercise recovery in heart failure. Am. J. Physiol. 276 (Heart Circ. Physiol. 45): H913–H917, 1999.— Recent studies have suggested that the increased ventilatory response during exercise in patients with chronic heart failure was related to the activation of muscle metaborecept...

Mukkamala, Ramakrishna, Joanne M. Mathias, Thomas J. Mullen, Richard J. Cohen, and Roy Freeman. System identification of closed-loop cardiovascular control mechanisms: diabetic autonomic neuropathy. Am. J. Physiol. 276 (Regulatory Integrative Comp. Physiol. 45): R905–R912, 1999.—We applied cardiovascular system identification (CSI) to characterize closed-loop cardiovascular regulation in patien...

Bestle, Morten Heiberg, Niels Vidiendal Olsen, Poul Christensen, Benny Vittrup Jensen, and Peter Bie. Cardiovascular, endocrine, and renal effects of urodilatin in normal humans. Am. J. Physiol. 276 (Regulatory Integrative Comp. Physiol. 45): R684–R695, 1999.—Effects of urodilatin (5, 10, 20, and 40 ng·kg21 ·min21) infused over 2 h on separate study days were studied in eight normal subjects wi...

2010.6 The National Institute on Alcoholism and Alcohol Abuse (NIAAA) formed a special task force to make recommendations to address the problem.7 Binge drinking has even received global attention from the World Health Organization, which convened a conference to address the topic.8 Several prominent organizations and key leaders have accepted this call to action. Mothers Against Drunk Driving ...

Fortenberry, James D., Marilyn L. Owens, and Lou Ann S. Brown. S-nitrosoglutathione enhances neutrophil DNA fragmentation and cell death. Am. J. Physiol. 276 (Lung Cell. Mol. Physiol. 20): L435–L442, 1999.—Enhancing the clearance of neutrophils by enhancing apoptotic cell death and macrophage recognition may be beneficial in acute lung injury. Exogenous nitric oxide gas depresses neutrophil oxi...

Ikejima, Kenichi, Nobuyuki Enomoto, Vitor Seabra, Ayako Ikejima, David A. Brenner, and Ronald G. Thurman. Pronase destroys the lipopolysaccharide receptor CD14 on Kupffer cells. Am. J. Physiol. 276 (Gastrointest. Liver Physiol. 39): G591–G598, 1999.—CD14 is a lipopolysaccharide (LPS) receptor distributed largely in macrophages, monocytes, and neutrophils; however, the role of CD14 in activation...

Jin, Lan, Lee Chao, and Julie Chao. Potassium supplement upregulates the expression of renal kallikrein and bradykinin B2 receptor in SHR. Am. J. Physiol. 276 (Renal Physiol. 45): F476–F484, 1999.—High potassium intake is known to attenuate hypertension, glomerular lesion, ischemic damage, and stroke-associated death. Our recent studies showed that expression of recombinant kallikrein by somati...