يا هچروم يدنب هشوخ متيروگلا ياراد پ ا ار يددعتم ياهرتم هلمج زا ،نتشادرب هب طوبرم ياهرتماراپ نتشاذگ اه هداد ديد عاعش ، يم هك دشاب ريثات و دنراد متيروگلا ييارگمه و دركلمع رد يدايز اطخ و شيامزآ تروص هب لاومعم نييعت يم رگ د دن . شور هلاقم نيا رد ي رب ينتبم CLA-PSO 1 ي هتسسگ لدم كي هك PSO دشاب يم يارب قيبطت كيتاموتا پ ياهرتمارا يا هچروم يدنب هشوخ يم داهنشيپ ددرگ . روظنم هب گلا ساسا رب هك د...

mTOR complex 2 (mTORC2) signaling is upregulated in multiple types of human cancer, but the molecular mechanisms underlying its activation and regulation remain elusive. Here, we show that microRNA-mediated upregulation of Rictor, an mTORC2-specific component, contributes to tumor progression. Rictor is upregulated via the repression of the miR-424/503 cluster in human prostate and colon cancer...

ﺤﻀـرت أﻏﺸـﻴﺔ SnO 2 وأﻏﺸـﻴﺔ اﻟﻤﺸـوﺒﺔ ﺒــ Ag O اﻟرﻗﻴﻘـﺔ وﺒﺎﻟﻨﺴـب
 
 اﻟوزﻨﻴـﺔ (%٥ ٬%٣) ﺒﺎﺴـﺘﺨدام طرﻴﻘـﺔ اﻟﺘرﺴـﻴب اﻟﻛﻴﻤﻴــﺎﺌﻲ اﻟﺤـ ارري ﻋﻠـﻰ ﻗواﻋـد ﻤــن
 زﺠﺎج اﻟﺒوروﺴﻠﻴﻛﺎت ﻋﻨد درﺠﺔ ﺤ اررة .( ٥٠٠ ºC )
 ﺘﻤـت د ارﺴـﺔ ﻨﻤـط ﺤﻴـود اﻷﺸـﻌﺔ اﻟﺴـﻴﻨﻴﺔ ﻟﻸﻏﺸـﻴﺔ اﻟﻤﺤﻀـرة وﺒـدرﺠﺎت ﺤـ اررة
 ﺘﻠـــدﻴن ٥٤٠ ٬ ٥٨٠ ٦٢٠) إذ أظﻬـــرت ﻨﺘـــﺎﺌﺞ ﺤﻴـــود اﻻﺸـــﻌﺔ اﻟﺴـــﻴﻨﻴﺔ أن
 اﻷﻏﺸﻴﺔ ذات ﺘرﻛﻴب ﺒ...

MicroRNAs (miRs) are post-transcriptional inhibitory regulators of gene expression acting by direct binding to complementary messenger RNA (mRNA) transcripts. Recent studies have demonstrated that miRs are crucial determinants of endothelial cell behavior and angiogenesis. We have provided evidence of the prominent role of miR-503 in impairment of postischemic reparative angiogenesis in the set...

Visceral leishmaniasis, a disease caused by Leishmania infantum chagasi, represents a major public health problem in many areas of the world. However, there is currently no vaccine for human use. The aim of this work was to purify the 503 antigen of Leishmania i. chagasi directly from unclarified Escherichia coli feedstock through expanded bed adsorption (EBA) chromatography. Batch experiments ...

Diabetic cardiomyopathy (DCM) is a common heart disease. The Phase II enzyme inducer (CPDT) is a complex enzyme that promotes the expression of antioxidant enzymes through activating nuclear factor erythroid 2-related factor 2 (Nrf2); these compounds have been shown to protect against oxidative stress. However, whether these compounds have similar protective effects in DCM still remains unclear...

تێکەلبوونا ژانرێن ئەدەبى مەبەست ژێ نەمانا سنورانە دناڤبەرا ئەدەبیدا کو نڤیسەر و رەخنەگر وەسا سەردەریێ ل گەل تێکستى دکەن چ چارچوڤەیێن دەستنیشانکرى نین، ژێر ناڤێ بیت، یان هەڤتێکستییێ لەورا چیرۆک ژى وەک ژانرەکێ پەخشانى ئەڤ دیاردا دناڤدا دهێتە دیتن. گریمانا ئەڤێ ڤەکولینێ ئەوە ژانرێ شیعرى د چیرۆکێن گوڤارا "پەیڤ"دا (1993-2003)، خزمەتا چیرۆکێ دابووینە نە، ب شێوەیەکێ هەرەمەکى خو دناڤ ئەوان تێکستێن چیرۆ...

The NF-kB pathway is key to epithelial immune defense and has been implicated in secretion of antimicrobial peptides, release of cytokines/chemokines to mobilize immune effector cells, and activation of adaptive immunity. The expression of many inflammatory genes following infection involves the remodeling of the chromatin structure. We reported here that histone deacetylases (HDACs) and NF-kB ...