PURPOSE To evaluate the expression of microRNAs in tissue samples from patients with bladder cancer and to compare it with healthy adjacent tissue samples as controls. MATERIALS AND METHODS Thirty five tissue samples from patients with newly diagnosed untreated bladder transitional cell carcinoma and 35 adjacent normal urothelium were collected during 2013 to 2014. TRIzol reagent was used to ...

In recent year, biocompatible, biodegradable materials (linear polylactic acid-based urethanes) in the solid and/or liquid form have attracted tremendous attention in biomedical application particularly in stent coating. Low molecular weight poly (lactic acid) s (PLA), having narrow molecular weight distribution was by dehydropolycondensation method using tetraphenyltin as a catalyst. Hydroxyl ...

Comparison of microRNA (miRNA) expression profiles in the noncancerous liver tissues adjacent to hepatocelluar carcinomas (HCCs) was a strategy to identify postoperative prognostic predictors in this study. Expression profiles of 270 miRNAs were determined in the paraneoplastic liver tissues of 12 HCC patients with known postoperative prognosis. A panel of candidate miRNA predictors was identif...

Objectives. We investigated the action of triptolide in rats with adriamycin-induced nephropathy and evaluated the possible mechanisms underlying its protective effect against podocyte injury. Methods. In total, 30 healthy male Sprague-Dawley rats were randomized into three groups (normal group, model group, and triptolide group). On days 7, 28, 42, and 56, 24 h urine samples were collected. Al...

The majority of human miRNA genes is transcribed by polymerase II and can be classified as class II genes similar to protein-coding genes. Whereas current research on miRNAs has focused on the physiological and pathological functions, the molecular mechanisms underlying their transcriptional regulation are largely unknown. We recently reported that lipopolysaccharide (LPS) alters mature miRNA e...

Antigen uptake, processing and presentation by antigen presenting cells (APCs) are tightly coupled processes which consequently lead to the activation of innate and adaptive immune responses. However, the regulatory role of microRNA (miRNAs) in these critical pathways is poorly understood. In this study, we show that overexpression of miR-24, miR-30b and miR-142-3p attenuates uptake and process...

Mercury emissions from coal fired power plants are generally measured using one of two methods electronic Continuous Emission Monitoring Systems (Hg CEMS) that most commonly use atomic fluorescence, or sorbent traps. Electronic Hg CEMS are often compared against sorbent traps using EPA’s Method 30B Relative Accuracy Test Audit (RATA). Because sorbent traps include mercury contained in the parti...

We address the problem of scalable distributed reasoning, proposing a technique for materialising the closure of an RDF graph based on MapReduce. We have implemented our approach on top of Hadoop and deployed it on a compute cluster of up to 64 commodity machines. We show that a naive implementation on top of MapReduce is straightforward but performs badly and we present several non-trivial opt...

A series of novel polyurethane network/organoclay nanocomposites (PUN-NCs) with different soft segment contents (30–60 wt%) was prepared by in situ polymerization solution and characterized. PU network (PUN) made from poly(dimethylsiloxane)-based macrodiol as the 4,4′-methylenediphenyldiisocyanate hyperbranched polyester third pseudo generation hard segment. Nanocomposites were obtained dispers...