The complete nucleotide sequence of the genomic RNAs of strains G2 and G7 of soybean mosaic virus were determined. In both cases, the genome is 9588 nucleotides long, excluding the 3'-terminal poly(A) sequence. A large open reading frame (nucleotides 132 to 9329) encodes a polyprotein of 3066 amino acids with a predicted M(r) of either 349542 (strain G2) or 349741 (strain G7). Based on comparis...

We isolated and identified naturally processed peptides selected by antigen-presenting cells homozygous for expression of I-A(g7) or I-A(d) class II MHC molecules, or from heterozygous antigen-presenting cells that express I-A(g7) along with I-A(g7PD) or I-A(d). Identification of large numbers of peptides demonstrated that despite being closely related on a structural level, each class II MHC m...

A stem-tip necrosis disease was observed in the soybean [Glycine max (L.) Merr.] cultivar Columbia and its derivative OX686 when infected with a necrosis-causing strain of Soybean mosaic virus (SMV) in Canada. A dominant gene named Rsv3 was found in OX686 for the necrotic reaction. In the present research we have found that Columbia is resistant to all known SMV strains G1-G7, except G4. Geneti...

The purpose of this paper is to investigate the short and long-run relationships between renewable, non-renewable energy consumption (NREC) economic growth. This study highlights importance renewable improve total factor productivity (TFP) in G20 countries spanning on 2002-2018. Using approach panel Feasible Generalized Least Squares (PFGLS) cross-section period weight FGLS sur robust, we have ...

A series of recent studies in humans and the NOD mouse model have highlighted the central role that autoimmunity directed against insulin, in particular the insulin B chain 9-23 peptide, may play in the pathogenesis of type 1 diabetes. Both pathogenic and protective T-cell clones recognizing the B:9-23 peptide have been produced. This report describes the successful creation of BDC12-4.1 T-cell...

In this paper I present new international comparisons of economic growth among the G7 nations—Canada, France, Germany, Italy, Japan, the U.K., and the U.S. (See the tables and charts pp. 154–166.) These comparisons focus on the impact of investment in information technology (IT) equipment and software over the period 1980–2000. In 1998 the G7 nations accounted for nearly sixty percent of world ...

CD4(+) T cells selected by the type 1 diabetes associated class II MHC I-A(g7) molecules play a critical role in the disease process. Multivalent MHC/peptide tetramers have been used to directly detect antigen-specific T cells. Detection of autoantigen-activated CD4(+) T cells with tetramers should be very helpful in the study of the roles of these cells in diabetes. We report here the generati...

A defect in mitochondrial protein synthesis has previously been identified in the respiration-deficient Chinese hamster lung fibroblast mutant V79-G7. The present work extends the characterization of this mutant. A more sensitive analysis has shown that mutant mitochondria synthesize all mitochondrially encoded peptides, but in significantly reduced amounts. This difference is also seen when is...

Human growth factor receptor-bound protein 7 (Grb7) is an adapter protein involved in cell growth, migration and proliferation. It is now recognized that Grb7 is an emerging therapeutic target in specific cancer subtypes. Recently, the discovery of a bicyclic peptide inhibitor that targets the Grb7 SH2 domain, named G7-B1, was reported. In an attempt to probe the foundation of its interaction w...