Sodium reabsorption through the epithelial sodium channel (ENaC) at the distal segment of the kidney plays an important role in salt-sensitive hypertension. We reported previously that hydrogen peroxide (H2O2) stimulates ENaC in A6 distal nephron cells via elevation of phosphatidylinositol 3,4,5-trisphosphate (PI(3,4,5)P3) in the apical membrane. Here we report that H2S can antagonize H2O2-indu...

(51) Int. Cl. CI2O I/68 (2006.01) A () IN 41/06 (2006.01) A0IN 43/653 (2006.01) A6 IK 31/18 (2006.01) A6 IK 31/41.96 (2006.01) G0IN 33/566 (2006.01) A6 IK 3 1/37 (2006.01) A6 IK 31/.407 (2006.01) A6 IK 31/433 (2006.01) A6 IK 31/435 (2006.01) C07C 69/017 (2006.01) C07C 31 I/21 (2006.01) C07C 335/22 (2006.01) C07D 215/06 (2006.01) C07D 221/06 (2006.01) C07D 22 1/18 (2006.01) C07D 231/12 (2006.01)...

The T-shaped amphiphilic molecule A6/6 forms a columnar hexagonal liquid-crystalline phase between the crystalline and the isotropic liquid when studied in bulk (Chen et al., 2005). Because of the hydrophilic and flexible oligo(oxyethylene) side chain terminated by a 1-acylamino-1-deoxy-d-sorbitol moiety attached to a rigid terphenyl core with terminal hexyloxy alkyl chains, it was expected tha...

Sporadic hand, foot, and mouth disease (HFMD) outbreaks and other infectious diseases in recent years have frequently been associated with certain human enterovirus (HEV) serotypes. This study explored the prevalences and genetic characteristics of non-HEV71 and non-coxsackievirus A16 (CV-A16) human enterovirus-associated HFMD infections in Shenzhen, China. A total of 2,411 clinical stool speci...

Coxsackieviruses A6 (CV-A6) and A16 (CV-A16) and Enterovirus 71 (EV-A71) have caused periodic epidemics of hand, foot and mouth disease (HFMD) among children in Singapore. We conducted a cross-sectional study to estimate the seroprevalence of these enteroviruses among Singapore children and adolescents. The study was conducted between August 2008 and July 2010. It involved 700 Singapore residen...

We designed and synthesized 26 prototype compounds and studied their anti-inflammatory activity and underlying molecular mechanisms. The inhibitory effects of the compounds on the production of nitric oxide (NO), cytokines, inflammatory-related proteins, and mRNAs in lipopolysaccharide (LPS)-stimulated macrophages were determined by the Griess assay, Enzyme linked immunosorbent assay (ELISA), W...

After 10 years of follow-up of a cohort of adolescents and young adults living in Munich, Tijssen et al (pp. 102–108) found that the persistence of affective symptoms earlier in life predicted later development of bipolar disorder in a dose–response fashion. They confirmed that although hypomanic symptoms are relatively common in adolescence, most resolve with time. In a Swedish national cohort...

Let E, E′ be isogenous elliptic curves over Q given by standardized Weierstrass models. We show that (in the obvious notation) a1 = a1, a ′ 2 = a2, a ′ 3 = a3 and, moreover, that there are integers t, w such that a4 = a4 − 5t and a6 = a6 − b2t − 7w, where b2 = a1 + 4a2.

Oldershaw et al (pp. 140–144) conducted a qualitative study to obtain parental perspectives on adolescent self-harm. Using an interpretative phenomenological approach, they identified four key themes relating to: the process of discovery of the behaviour; making sense of the behaviour; the psychological impact of selfharm on parents; and the effect of adolescent self-harm on parenting and famil...