نتایج جستجو برای: ژن stk11

تعداد نتایج: 16599  

2017
Seungmin Ham Sarah J. Meachem Catherine S. Choong Adrian K. Charles Gareth S. Baynam Timothy W. Jones Nirukshi U. Samarajeewa Evan R. Simpson Kristy A. Brown

(2013). Overexpression of aromatase associated with loss of heterozygosity of the STK11 gene accounts for pepubertal gynecomastia in boys with Peutz-Jeghers Syndrome. Take down policy If you believe this document infringes copyright, raise a complaint by contacting [email protected]. The document will be immediately withdrawn from public access while the complaint is being investigated.

Journal: :The Journal of clinical endocrinology and metabolism 1998
C A Stratakis L S Kirschner S E Taymans I P Tomlinson D J Marsh D J Torpy C Giatzakis D M Eccles J Theaker R S Houlston J L Blouin S E Antonarakis C T Basson C Eng J A Carney

Carney complex (CC), Peutz-Jeghers syndrome (PJS), Cowden disease (CD), and Bannayan-Zonana syndrome (BZS) share clinical features, such as mucocutaneous lentigines and multiple tumors (thyroid, breast, ovarian, and testicular neoplasms), and autosomal dominant inheritance. A genetic locus has been identified for CC on chromosome 2 (2p16), and the genes for PJS, CD, and BZS were recently identi...

Journal: :Clinical chemistry 2009
Sandra Regina Jean-Baptiste Valentin Sébastien Lachot Etienne Lemarié Jérôme Rollin Yves Gruel

BACKGROUND Tissue factor (TF), the main initiator of blood coagulation, is also a signaling protein that regulates cancer progression. TF synthesis was recently shown to be affected by tumor suppressor genes (TSGs) in tumor cell lines. We therefore studied TF gene (F3) expression and the status of genes coding for tumor protein p53 (TP53), phosphatase and tensin homolog (PTEN), and serine/threo...

2018
Bingli Zheng Jie Peng Ablikim Mollayup Ahmat Bakri Lei Guo Jianjiang Zheng Hui Xu

Pancreatic cancer (PC) is associated with high mortality rates and poor prognoses. Pancreatic adenocarcinoma is the most common type of PC, and almost all cases of pancreatic adenocarcinoma are pancreatic ductal adenocarcinoma (PDAC). The aim of the current study was to reveal the genes involved in the prognosis of PDAC. Five datasets, including GSE71729 (145 PDAC samples and 46 normal samples)...

Journal: :Carcinogenesis 2010
Martha L Slattery Jennifer S Herrick Abbie Lundgreen Francis A Fitzpatrick Karen Curtin Roger K Wolff

Serine/threonine protein kinase 11 (STK11) and phosphatase tensin homolog deleted on chromosome 10 (PTEN) link insulin sensitivity and metabolic signaling to inflammation and other hormonal factors and colorectal cancer. We evaluate genetic variation in nine genes in a candidate pathway as follows: STK11 (3 tagSNPs), PTEN (9 tagSNPs), FRAP1 (mTOR) (4 tagSNPs), TSC1 (14 tagSNPs), TSC2 (8 tagSNPs...

2012
Matthew D. Wilkerson Xiaoying Yin Vonn Walter Ni Zhao Christopher R. Cabanski Michele C. Hayward C. Ryan Miller Mark A. Socinski Alden M. Parsons Leigh B. Thorne Benjamin E. Haithcock Nirmal K. Veeramachaneni William K. Funkhouser Scott H. Randell Philip S. Bernard Charles M. Perou D. Neil Hayes

BACKGROUND Lung adenocarcinoma (LAD) has extreme genetic variation among patients, which is currently not well understood, limiting progress in therapy development and research. LAD intrinsic molecular subtypes are a validated stratification of naturally-occurring gene expression patterns and encompass different functional pathways and patient outcomes. Patients may have incurred different muta...

Journal: :Japanese Journal of Cancer Research 1999

Journal: :Electronic Journal of General Medicine 2007

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