Seapolynol (SN) is a polyphenol mixture derived from Ecklonia cava. We evaluated the effects of SN on lipid accumulation in adipocytes, zebrafish, and mice. SN effectively inhibited lipid accumulation in three experimental models by suppressing adipogenic factors. Triglyceride synthetic enzymes such as diacylglycerol acyltransferase 1 (DGAT1) and GPAT3 were also downregulated by SN. This SN-ind...

Irinotecan (CPT-11) is a clinically important anticancer prodrug that requires enzymatic hydrolysis by carboxyesterase to generate the active metabolite SN-38. However, SN-38 is further metabolized to inactive SN-38 glucuronide (SN-38G), thus diminishing the levels of active SN-38. Although exogenously administered glucuronide drugs are being investigated for cancer therapy, it is unknown if en...

In the title compound, [Sn(C(6)H(11))(3)(C(7)H(3)Br(2)O(3))], the Sn atom is four-coordinate and possesses a distorted Sn(C(3)O) tetra-hedral geometry, with Sn-C bond lengths in the range 2.132 (6)-2.144 (6) Å and with Sn-O = 2.086 (4) Å. The uncoordinated carboxyl-ate O atom forms a weak contact with the Sn atom, with an Sn⋯O separation of 2.962 (2) Å.

In this research Na-Y was synthesized by hydrothermal method and used as support for preparation of Sn/Pt/Na-Y catalysts using two different tin precursors, Bu3Sn(Cl) and SnCl2.2H2O, by sequential impregnation, in which the Pt  was deposited first and in the next step Sn was deposited. The catalysts were characterized by H2 chemisorption, transmis...

The structure and vibrational dynamics of room-temperature-grown nanoscale Sn/amorphous (a-!Si multilayers have been studied by x-ray diffraction, Raman scattering, Sn Mössbauer spectroscopy, and Sn nuclear-resonant inelastic x-ray scattering ~NRIXS! of synchrotron radiation. With increasing Sn-layer thickness, the formation of b-Sn was observed, except at the Sn/Si interfaces, where a 10-Å-thi...

INTRODUCTION Systemic lupus erythematosus (SLE) is a chronic inflammatory condition with multisystem involvement. One of the key features of the disease is the upregulation of type I interferons, resulting in the so-called "interferon signature". Recent flow cytometric and transcriptomic studies identified Sialoadhesin (Sn, CD169) as an important interferon-induced blood monocyte biomarker in d...

The substantia nigra (SN) is crucial to the propagation of seizures in kindled rats and in other experimental seizure models. However, the mechanisms by which the SN acts to facilitate the propagation of seizures are unknown. To investigate these mechanisms we quantified the activity of SN neurons during seizures in kindled and naive rats in a paralyzed, ventilated state and examined the relati...

Several previous studies reported that sn-2 acyl lysophosphatidylcholines (LPCs) undergo rapid isomerization due to acyl migration, especially at physiological pH and temperature. However, these studies have been carried out using mostly sn-2 palmitoyl LPC, whereas the naturally occurring sn-2 LPCs are predominantly unsaturated. In this study, we investigated the acyl migration in four naturall...