Persistent infections of hepatitis C virus (HCV) are known to be a major risk factor for causing hepatocellular carcinomas. Nonstructural protein 3 (NS3) of HCV has serine protease and RNA helicase domains, and is essential for the viral replication. Further, NS3 is also considered to be involved in the development of HCV-induced hepatocellular carcinomas. In this report, we focus on the functi...

Introduction: Grapsus albolineatus is thought to have a high concentration of carotenoid pigments. Although studies on male G. been conducted, no pigment extraction from female carried out. Carotenoids ability fight free radicals. Previous research has shown that carotenoids can radicals cause premature skin-aging. The purpose thi...

Hepatitis C virus (HCV) variation in specific T-cell epitopes may represent a mechanism of viral persistence in chronic infection. We examined the HCV non-structural protein 3 (NS3), including the immunologically relevant epitopes HCV NS3-2 KLVALGINAV (human leukocyte antigen [HLA]-A2-restricted) and HCV NS3-1391 LIFCHSKKK (HLA-A3-restricted), in 22 HLA-A2+ patients with chronic infection. Sign...

Background: Photo-electro-chemical (PEC) water splitting represents a promising technology towards an artificial photosynthetic device but many fundamental electronic processes, which govern long-term stability and energetics, are not yet fully understood. X-ray absorption spectroscopy (XAS), particularly its high energy resolution fluorescence-d...

Background: pulmonary tuberculosis (PTB) is one of the most global dangerous infectious diseases worldwide, particularly in developing countries. Mycobacterium tuberculosis (Mtb) agent that caused PTB transferred by air droplets from person to other. In present epidemiological study, we aimed ...

introduction: long term complications of hepatitis c virus (hcv) infection include fibrosis, cirrhosis, and hepatocellular carcinoma and although the disease is treatable with the newly introduced direct acting antivirals, but factors such as drug resistance, viral genotype and adverse effects can limit the effectiveness of therapy. therefore, development of effective, safe and affordable proph...

Background: Autophagy (self-feeding) assists survival of starving cells by partial self-digestion, while dormancy as cysts, spores or seeds enables long-term survival. Starving Dictyostelium amoebas construct multicellular fruiting bodies with and stalk cells, many Dictyostelia still able to encyst individually like their single-celled ancest...

Background: In the Clean Sky 2 project DIMES, cyclic loading of a section an A320 wing with pre-existing damage was carried out. Methods: We present Digital Image Correlation (DIC) prototype system to monitor crack propagation in aircraft wing. This includes mount for easy installation and adjustment confined space. ...

Background: Low frequency mutations within the filaggrin (FLG) gene are established genetic risk factors for atopic dermatitis. Studies of FLG have typically used sequencing or bespoke genotyping. Large-scale population cohorts with genome-wide imputed data offer powerful analysis opportunities, but FLG </...

BACKGROUND To support clinical development of HCV non-structural protein (NS) 3 protease inhibitors (PIs), phenotypic monitoring of patient isolates is a prerequisite for understanding the emergence of resistance. HCV isolates typically fail to replicate in cell culture, necessitating the use of alternative phenotyping methods. METHODS An NS3 protease chimeric replicon system was developed to...