OBJECTIVE Clinical depression is associated with multiple abnormalities of immune function, including reduced virus-specific responses. This study tested the hypothesis that the Flinders Sensitive Line (FSL) rat, a promising genetic animal model of depression, would exhibit reductions in antigen-specific primary antibody responses to immunization. METHODS FSL (N = 13) and control Flinders Res...

OBJECTIVE To evaluate tumor growth in a series of patients undergoing liver resection after portal vein embolization (PVE). BACKGROUND The regenerative response after PVE leading to compensatory hypertrophy of the nonembolized liver segments potentially enhances tumor growth. METHODS Portal vein embolization was performed in 28 patients diagnosed with colorectal metastases between 2004 and ...

BACKGROUND As surgical resection of colorectal liver metastases (CLM) remains the only treatment for cure, efforts to extend the surgical indications to include patients with multiple bilobar CLM have been made. This study evaluated the long-term outcome, safety and efficacy of two-stage hepatectomy (TSH) for CLM in a large cohort of patients. METHODS Patients undergoing surgery between Decem...

In this paper, we consider a distributed reinforcement learning setting where agents are communicating with central entity in shared environment to maximize global reward. A main challenge is that the randomness of wireless channel perturbs each agent’s model update while multiple agents’ updates may cause interference when under limited bandwidth. To address issue, propose novel ...

An optical fiber temperature sensor based on Mach–Zehnder interferometer and thermo-optic effect of the liquid crystal (LC) in ring laser (FRL) system is proposed experimentally demonstrated. The LC infiltrated into core hollow fiber, resonant wavelength more sensitive to variation due interaction between incident light cavity infiltrating with high thermal coefficient. Meanwhile, FRL was furth...

Abstract Introduction In patients with major depressive disorder, up to 68% present comorbid sexual dysfunction, which resolves in only 5% 30% of treated antidepressants. Several groups antidepressants negatively affect function. Objective The study investigated whether a newly developed amine transport inhibitor, IP2018, improves depression and erectile function the same dose range. Methods do...

Serotonin (5HT) is crucial to normal reflex vagal modulation of heart rate (HR). Reduced baroreflex sensitivity (sBRS) and HR variability (HRV) reflect impaired neural, particularly vagal, control of HR and are independently associated with depression. In conscious, telemetered Flinders-Sensitive Line rats (FSL), a well-validated animal model of depression, we tested the hypothesis that cardiov...

Large-scale investigations aimed at elucidating the molecular mechanism of action of antidepressant treatment are achievable through the application of proteomic technologies. We performed a proteomic study on the Flinders Sensitive Line (FSL), a genetically selected rat model of depression, and the control Flinders Resistant Line (FRL). To evaluate gene-environment interactions, FSL and FRL an...