نتایج جستجو برای: ژن های p14
تعداد نتایج: 483007 فیلتر نتایج به سال:
CDK5 regulatory subunit associated protein 3 (CDK5RAP3) is a novel activator of PAK4 and processes important pro-metastatic function in hepatocarcinogenesis. However, it remains unclear if there are other mechanisms by which CDK5RAP3 promotes HCC metastasis. Here, we showed that in CDK5RAP3 stable knockdown SMMC-7721 HCC cells, p14(ARF) tumor suppressor was upregulated at protein and mRNA level...
در این تحقیق شناسائی اپیتوپ های غالب تحریک کننده سیستم ایمنی اختصاصی سلول های t و بواسطه آن طراحی کاست ژنی وابسته به پنج پروتئین اکینوکوکوس گرانولوزوس شامل eggst, ega31, eg95, egtrp, p14-3-3 و بررسی پاسخ ایمنی آن انجام گرفت. اپیتوپ ها با نرم افزار های propred و iedbبا بهترین قدرت اتصال به مولکول های mhc پیش بینی شدند. پس از سنتز dna، قطعه مورد نظر داخل وکتور بیانی pet41a+ کلون شد به منظور فهم ب...
A phenotypically normal mother had two apparently balanced translocations involving chromosomes 5, 7, and 12. Her karyotype was 46,XX,t(5;7) (5;12) (p14q34;p14;q21), while her daughter, who was also phenotypically normal, had inherited only one of the translocations. Her karyotype was 46,XX,-5,-7,+rec(5)t(5;7) (q34;p14)mat,+der(7)t(5;7) (q34;p14)mat. The other was lost during a meiotic crossing...
Idiopathic pulmonary fibrosis (IPF) is a devastating lung disease of unknown etiology. A conspicuous feature is the formation and persistence of fibroblastic/myofibroblastic foci throughout the lung parenchyma. Mechanisms remain unknown, but data indicate that fibroblasts acquire an antiapoptotic phenotype. We hypothesized that transcriptional silencing of proapoptotic genes may be implicated, ...
زمینه و هدف: کیست هیداتیک در اثر آلودگی با لارو انگل اکینوکوکوس گرانولوزوس ایجاد میشود. در مرحله لاروی این انگل آنتیژنهای متعددی تولید میشود که یکی از این آنتیژنها، آنتیژنی از خانواده پروتئینهای p14-3-3 میباشد و واکسن نوترکیب آن ایمنی‌زایی قابل توجهی را در موش القا کرده است. با توجه به ایمونوژنتر بودن نواحی اپیتوپی آنتیژنها و تولید پاسخ ایمنی Th1 مطلوب هدف از این مطالعه کلون کردن ...
Background and purpose: Ghrelin, a natural ligand of the growth hormone secretagogue receptor plays a major role in regulation of appetite, body fat mass, and energy balance in the body. The aim of this study was to evaluate the effects of maternal diabetes on circulatory ghrelin levels in rat newborns. Materials and methods: In this experimental study, female Wistar rats were allocated into d...
BACKGROUND This meta-analysis was performed to investigate the relationship between methylation of the P14 and O6-methylguanine-DNA methyltransferase (MGMT) genes and the risk of hepatocellular carcinoma (HCC). MATERIALS AND METHODS We searched PubMed, EMBASE, the Chinese Biomedical Database (CBM), and the China National Knowledge Infrastructure (CNKI) databases to identify relevant studies t...
The tumour suppressor ARF (alternative reading frame) is one of the most important oncogenic stress sensors. ARF provides an 'oncogenic checkpoint' function through both p53-dependent and p53-independent mechanisms. In the present study, we demonstrate a novel p53-independent interaction between p14(ARF) and the adenovirus oncoprotein E1A. p14(ARF) inhibits E1A transcriptional function and prom...
Melanoma genomes contain thousands of alterations including: mutations, copy number alterations, structural aberrations, and methylation changes. The bulk of this variation is stochastic and functionally neutral, with only a small minority representing "drivers" that contribute to the genesis and maintenance of tumors. Drivers are often directly or inversely correlated across tumors, reflecting...
The prognostic significance of the inactivation of the p16, p15, and p14 genes has been reported in lymphoid malignancies in humans. To evaluate the relationship between inactivation of the p16, p15, and p14 genes and prognosis in canine high-grade lymphoma, primary tumor cell samples obtained from 71 dogs with high-grade lymphoma were examined for the expression levels of these genes. Quantita...
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