Background: CPI-0209 is an investigative oral, small-molecule, second-generation, selective inhibitor of enhancer zeste homolog 2 (EZH2), a histone methyltransferase and the catalytic subunit polycomb repressive complex 2, which frequently overexpressed in cancers correlates with poor prognosis. In Phase 1, dose 350 mg once daily (QD) 28-day cycles was selected for initiation based on pharmacok...

Many temperature sensing applications require galvanic isolation of the sensor. Fortunately, several low-cost temperature-sensing integrated circuits (ICs) are easy to isolate. This application note shows two approaches to isolating temperature sensors. Sensors, such as temperature sensors, require galvanic isolation when they are mounted in "mechanically inconvenient" locations such as electri...

Target audience: Researchers and engineers who have interest in RF transmit technology in high field MRI. Purpose: The B1 inhomogeneity is one of the problems for breast imaging at 3 T. Various methods using multiple channel RF transmit coil or using some additional dielectric absorptive material are investigated to overcome this problem [1, 2]. These studies showed the number of channels of RF...

domain. The safeness of the analysis is veri ed by formalising a correspondence between the concrete domain and the abstract domain and proving that the abstract operators safely simulate the concrete operators with respect to the correspondence [11]. One way to formalise the correspondence is by a function, called an abstraction (function), from the concrete domain to the abstract domain. We a...

A conflict exists between field biologists and physiologists (“functional biologists” or “evolutionary ecologists”) on the one hand and those working in molecular evolution (“evolutionary biologists” or “population geneticists”) on the other concerns the relative importance of natural selection and genetic drift. This paper is concerned with this issue in the case of vertebrates such as birds, ...

In order to investigate some problems of geophysical interest, the usual consideration of symmetrical or antisymmetrical loading of an isotropic homogeneous plate containing a crack was extended to the case where the alignment of the crack separates two separate isotropic homogeneous regions. It develops that the modulus of the singular behavior of the stress remains proportional to the inverse...

Syntax: P 2 Program TD 2 Type-Declaration T, S, U 2 Type-Name MD 2 Method-Declaration F* 2 Formal-List F 2 Formal B 2 Body D 2 Declaration E 2 Expression g 2 Method-Name E* 2 Expression-List C 2 Command M 2 Main I 2 Identi er N 2 Numeric-literal P ::= TD MD M TD ::= j type I fields ( F* ) j TD1 ; TD2 FD ::= j I : T j FD1 ; FD2 T ::= I MD ::= j method I ( F* ) : T f B g j MD1 ; MD2 F* ::= j F F*...