Dairy cows that are being cared for in family businesses were used to compare the pregnancy rates by applying different time periods, using progesterone devices, and fixed-time artificial inseminations. The randomly divided into 3 groups. Group 1(n = 56); On day 0, GnRH (IM) (10mg Buserelin acetate, Ovarelin, CEVA DIF) + Progesterone implants (PRID®) (1,55 g CEVA), Day 8 PGF2α (Dinoprost tromet...

Background and Aim: Oxidative stress, caused by environmental insults, may interfere with redox signaling during pregnancy is a known contributor to preterm birth. In vivo in vitro studies indicate that PFAS generate reactive oxygen species, but this has been minimally investigated humans not examined pregnancy. We the effects of prenatal exposure on oxidative stress biomarkers, hypothesizing w...

To evaluate the effect of intrauterine cephapirin on treatment of endometritis 39 Holstein dairy cows that affected with postpartum endometritis were selected and randomly assigned to two experimental designs. In experiment 1, 6 out of 14 cows were 25 to 30 days after parturition were treated by intrauterine oxytetracycline. Another 8 cows were treated by intrauterine cephapirin (Metri-Care). I...

Pulsatile release of uterine prostaglandin F2α(PGF2α) induces luteolysis in ruminants. However, the mechanism(s) that initiates and maintains luteolysis has not been defined. The present study tested the hypothesis that the endogenous PGF2α pulse generator is uterine-derived platelet-activating factor (PAF). Ovariectomized ewes were given exogenous progesterone (P), estradiol (E), or both (P+E,...

Many estrus synchronization protocols aim to induce a new follicular wave to improve response and enhance pregnancy rate. Our objectives were to determine the effectiveness of GnRH analog administered d 0 and 9 during an extended controlled internal drug release (CIDR) protocol to produce 2 follicular waves, induce cyclicity in anestrus cows, and evaluate the effi cacy of a single 50-mg dose of...

In China, escin has been widely used in the clinic as a potent anti-inflammatory drug. Previous studies have indicated that escin exerts its anti-inflammatory effect by enhancing the release of glucocorticoids (GCs) and prostaglandin-F2α (PGF2α), and this has been documented in the drug description. However, our previous studies demonstrated that escin did not increase the secretion of GCs, but...

Consequences of primary dsysmenorrhea (PD) can be severe. Increased prostaglandin production leads to uterine contraction and insufficient blood flow to the endometrium causing ischemia and pain symptoms. Protein tyrosine kinase/phosphatase activities contribute to the modulation of uterine contraction. In our previous study, we found the synthetic β-methoxyacrylates compound Fluacrypyrim (FAPM...

OBJECTIVE Intrahepatic cholestasis of pregnancy (ICP), characterized by skin pruritus and elevation of serum aminotransferase activity and bile acid concentration in the mother, is one of the most common liver disorders in pregnancy. It was proved that ICP might lead to fetal distress by triggering oxidative damage. Total bile acids (TBA) are an established marker for assessment of the severity...

Ovulation is induced by the preovulatory surge of luteinizing hormone (LH) that acts on the ovary and triggers the rupture of the preovulatory ovarian follicle by stimulating proteolysis and apoptosis in the follicle wall, causing the release of the mature oocyte. The pro-inflammatory cytokine tumor necrosis factor α (TNFα) and prostaglandin (PG) F2α (PGF2α) are involved in the control of ovula...

The aim of the present study was to assess the effect of gestational hypercholesterolaemia on the prostaglandin-induced uterine response in late pregnant mouse uterus. Gestational hypercholesterolaemia was developed in Swiss albino mice feeding a diet (HFHC diet) containing 1.25 % cholesterol, 0.5 % sodium cholate and 15 % fat for 6 weeks before mating and continuing up to the 19th day of gesta...