Irritable bowel syndrome and interstitial cystitis frequently overlap. We have shown that acute colitis sensitizes urinary bladder afferents to both mechanical and chemical stimuli and that chronic colitis similarly produces neurogenic cystitis. We hypothesize that chronic irritation of the colon releases neuropeptides from bladder afferents, leading to receptor sensitization and neurogenic inf...

Good flow and pressure control is essential for successful Underbalanced Drilling (UBD) operations. This work evaluates the use of Model Predictive Control (MPC) for integrated control of well conditions and the topside separation system during UBD. The downhole well pressure, separator liquid levels, and the separator pressure are controlled by manipulation of the rig pump, the choke, and the ...

The AAA (ATPase associated with various cellular activities) p97 [also known as VCP (valosin-containing protein)] participates in numerous biological activities and is an essential component of the ubiquitin signalling pathway. A plethora of adaptors have been reported for p97, and increasing evidence is suggesting that it is through adaptor binding that p97 is diverted into different cellular ...

The activation of the TRPM8 channel, a member of the large class of TRP ion channels, has been reported to be involved in overactive bladder and painful bladder syndrome, although an endogenous activator has not been identified. In this study, N-(3-aminopropyl)-2-{[(3-methylphenyl) methyl]oxy}-N-(2-thienylmethyl)benzamide hydrochloride salt (AMTB) was evaluated as a TRPM8 channel blocker and us...

GTP cyclohydrolase 1 (GTPCH1) is the rate-limiting enzyme in the de novo synthesis of tetrahydrobiopterin (BH4). GTPCH1 protein degradation has been reported in animal models of several diseases, including diabetes mellitus and hypertension. However, the molecular mechanisms by which GTPCH1 is degraded remain uncharacterized. Here we report a novel non-covalent interaction between polyubiquitin...

Post-translational K63-linked poly-ubiquitination of AKT is required for its membrane recruitment and phosphorylation dependent activation in response to growth-factor stimulation. Current assays for target specific poly-ubiquitination involve cumbersome enzymatic preparations and semi-quantitative readouts. We have engineered a reporter that can quantitatively and in a target specific manner r...

A distributed drift-flux model and a low-order lumped model describing a multiphase (gas-liquid) flow in the well during Under-Balanced Drilling (UBD) has been presented. This paper presents a novel nonlinear adaptive observer to estimate the total mass of gas and liquid in the annulus and production constant of gas and liquid from the reservoir into the well during UBD operations. Furthermore,...

The articles [19], [25], [14], [10], [1], [16], [2], [3], [24], [11], [18], [9], [26], [6], [17], [7], [8], [12], [13], [20], [15], [4], [5], [21], [23], and [22] provide the notation and terminology for this paper. One can prove the following propositions: (1) For every non constant standard special circular sequence f holds BDD L̃(f) = RightComp(f) or BDD L̃(f) = LeftComp(f). (2) For every non ...