Although from the time of Koch onwards there had been desultory experiments with a variety of gold preparations in the management of pulmonary tuberculosis, gold as a recognised and accepted treatment did not emerge until 1925. In that year Holger Mollgaard of Copenhagen introduced sanocrysin, a double thiosulphate of gold and sodium, with which he had conducted an extensive series of animal ex...

Dr. Janet Rowley was internationally renowned for her studies of chromosome abnormalities in human leukemia and lymphoma. We adored her closer to home as a University of Chicago lifer and a treasured member of our great Hyde Park/Kenwood community. A woman of tremendous grace and beauty, she distinguished herself not only for her historic scientific discoveries but also with her sustained effor...

Sir William Osler (Figure 1) arrived in Britain in 1905 determined not only to guide Oxford medicine as its Regius Professor but also to improve the standard of postgraduate medicine throughout Britain. He felt that each county hospital should have a postgraduate department, using the argument that without postgraduate education a doctor was stale in five years, in the rut by ten years, and by ...

Mary Frances Lyon Mary Lyon was one of the most notable geneticists of the 20th century. She is renowned for her discovery of X inactivation, an early example of epigenetic gene regulation, but she alsomade fundamental contributions to the entire field of genetics. Mary was born on May 15, 1925 in Norwich, in the rural east of the United Kingdom. She was the first child of Clifford James Lyon, ...

V ictor L. Klee passed away on August 17, 2007, in Lakewood, Ohio. Born in San Francisco in 1925, he received his Ph.D. in mathematics from the University of Virginia in 1949. In 1953 he moved to the University of Washington in Seattle, where he was a faculty member for 54 years. Klee specialized in convex sets, functional analysis, analysis of algorithms, optimization, and combinatorics, writi...

"With poetry, the tune is in the words themselves-and once you begin to hear it, it will stay with you." Richard P. Korf, notes to his narration of John Brown's Body.

Generations of clinicians have been faced with often striking developmental and acquired hormonal syndromes associated with reproductive, growth, and metabolic phenotypes. These syndromes have included ambiguous genitalia, anomalies of sexual development, intersex forms, accelerated or delayed puberty, gigantism, and short stature. Although clinical phenotypes of these disorders have been well-...