نتایج جستجو برای: پروتئین bdnf

تعداد نتایج: 26807  

Journal: :The Journal of neuroscience : the official journal of the Society for Neuroscience 2012
Jennifer C Wilhelm Mei Xu Delia Cucoranu Sarah Chmielewski Tiffany Holmes Kelly Shukkwan Lau Gary J Bassell Arthur W English

After peripheral nerve injury, neurotrophins play a key role in the regeneration of damaged axons that can be augmented by exercise, although the distinct roles played by neurons and Schwann cells are unclear. In this study, we evaluated the requirement for the neurotrophin, brain-derived neurotrophic factor (BDNF), in neurons and Schwann cells for the regeneration of peripheral axons after inj...

پایان نامه :وزارت علوم، تحقیقات و فناوری - دانشگاه سیستان و بلوچستان - دانشکده علوم پایه 1390

مقدمه: اسکیزوفرنی نوعی از بیماری های روانی است که 1% جمعیت را تحت تأثیر قرار می دهد. دوپامین یکی از انتقال دهنده های اصلی در مغز است و رسپتورهای آن با تعدادی از اختلالات روانی مانند اسکیزوفرنی در ارتباط هستند. هیپرمتیلاسیون dna در نواحی پروموتر ژن ها نقش اساسی در کاهش بیان ژن های دخیل در بعضی از بیماری ها را دارد. رسپتورهای دوپامین در خاطره اپیزوتیک، ادراک، آگاهی و احساسات دخیل هستند که این اعم...

Journal: :basic and clinical neuroscience 0
mohsen marzban ali shahbazi mahdi tondar mansooreh soleimani masoomeh bakhshayesh arash moshkforoush

introduction: it has shown that listening to mozart music can potentiate spatial tasks in human and reduce seizure attacks in epileptic patients. a few studies have reported the effects of prenatal plus postpartum exposure of mice to the mozart music on brain-drived neurotrophic factor (bdnf) in the hippocampus. here we investigated the effect of postpartum exposure to the mozart music on bdnf ...

Journal: :The American journal of psychiatry 2012
Adam Tripp Hyunjung Oh Jean-Philippe Guilloux Keri Martinowich David A Lewis Etienne Sibille

OBJECTIVE The subgenual anterior cingulate cortex is implicated in the pathology and treatment response of major depressive disorder. Low levels of brain-derived neurotrophic factor (BDNF) and reduced markers for GABA function, including in the amygdala, are reported in major depression, but their contribution to subgenual anterior cingulate cortex dysfunction is not known. METHOD Using polym...

Journal: :The Journal of neuroscience : the official journal of the Society for Neuroscience 2002
Gianluca Gallo Alan F Ernst Steven C McLoon Paul C Letourneau

Growing axons during development are guided to their targets by the activity of their growth cones. Growth cones integrate positive and negative guidance cues in deciding the direction in which to extend. We demonstrated previously that treatment of embryonic retinal ganglion cells with brain-derived neurotrophic factor (BDNF) protects their growth cones from collapse induced by nitric oxide (N...

Journal: :The Journal of neuroscience : the official journal of the Society for Neuroscience 2014
Jian Xin Ling Ma Tian-Yi Zhang Hui Yu Yue Wang Liang Kong Zhe-Yu Chen

Brain-derived neurotrophic factor (BDNF) and its receptor, tropomyosin-related kinase receptor B (TrkB), play a critical role in memory extinction. However, the detailed role of BDNF in memory extinction on the basis of neural circuit has not been fully understood. Here, we aim to investigate the role of BDNF signaling circuit in mediating conditioned taste aversion (CTA) memory extinction of t...

Journal: :Diabetes 2021

Moods and metabolism modulate each other. High comorbidity of depression metabolic disorders, such as diabetes obesity, poses a great challenge to treat conditions. Here we report the therapeutic efficacy brain-derived neurotrophic factor (BDNF) by gene transfer in dorsal raphe nucleus (DRN) chronic unpredictable mild stress model (CUMS) models obesity. In CUMS, BDNF-expressing mice displayed a...

2016
Eugene Klimov

Brain-derived neurotrophic factor (BDNF) is a neurotrophin presented widely in central nervous system (CNS). The general function of BDNF in CNS is maintaining neuronal viability in ischemic condition, as well as providing neuronal plasticity and modulating behavioral activity. BDNF regulates axonal growth and differentiation of neurons; synapse formation; activity of dopaminergic, serotoninerg...

Journal: :Genetics and molecular research : GMR 2013
K Suriyaprom R Tungtrongchitr K Thawnashom Y Pimainog

Many studies have suggested that brain-derived neurotrophic factor (BDNF) is involved in the reward system of addiction, and that nicotine may induce alterations in BDNF gene expression and its protein level within the mesocorticolimbic system. We investigated the BDNF levels and biochemical-hematological parameters of smoker and non-smoker groups, and examined the association of the Val66Met B...

Journal: :Biological psychiatry 2013
Dekel Taliaz Vini Nagaraj Sharon Haramati Alon Chen Abraham Zangen

BACKGROUND Impaired neuronal plasticity and, specifically, altered expression of brain-derived neurotrophic factor (BDNF) were shown to play a critical role in depressive behavior and the mechanism of various antidepressant treatments including electroconvulsive therapy (ECT). Interestingly, opposing roles were suggested for BDNF in the hippocampus and the ventral tegmental area (VTA), while in...

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