نتایج جستجو برای: پروبیوتیک abt 10
تعداد نتایج: 1019339 فیلتر نتایج به سال:
ABT-751 is an orally bioavailable sulfonamide with antimitotic properties. A nonrandomized phase 1 dose-escalation study of ABT-751 in combination with CAPIRI (capecitabine and irinotecan) and bevacizumab was conducted to define the maximum tolerated dose, dose-limiting toxicity (DLT), and pharmacokinetics in patients with advanced colorectal cancer. Patients were treated with ABT-751 daily for...
ownload sion of apoptosis is a known feature of cancer cells. One mechanism of deregulating the apoptotic paththrough overexpression of antiapoptotic BCL2 family members. ABT-263 (navitoclax) is a first-in-class family inhibitor that restores the ability of cancer cells to undergo apoptosis. However, many cancer re resistant to ABT-263 due to high levels of a BCL2 family member, MCL1, which is ...
Abstract The inhibitive action of 2-aminobenzothiazole (ABT) on the corrosion AA6061-T6 was evaluated in 0.5 M HCl by electrochemical techniques. results were validated theoretical calculations using density functional theory (DFT). ABT showed a mixed inhibitor behaviour with 71–90% inhibition efficiency 1 × 10 ?4 to ?3 concentration range and at 303 323 K temperature. power increases its rise ...
The aim of this research were investigated bamboo-based activated charcoal (ABT)characteristics using Scanning Electron Microscopy (SEM) and Fourier Transform Infrared (FTIR). ABT has been successfully synthesized through physico-chemical activation at 700°C with H3PO4 10% solution as activator. resulted porous surface structure bamboo causes an absorption interaction pollutants (cations, anion...
BACKGROUND The balance between Th17 cells and regulatory T (Treg) cells has been shown to play an important role in the development of rheumatoid arthritis (RA). Recent studies have shown that treatment with abatacept (ABT) or tocilizumab (TCZ) affects Th17 and Treg cell populations. Although not unanimously accepted, several reports have shown that Treg cells are decreased by ABT and increased...
BACKGROUND Postoperative blood loss may be a risk factor for allogeneic blood transfusion (ABT) in patients undergoing subcapital hip fracture (SHF) repair. We investigated the utility and costs of using a low-vacuum reinfusion drain (Bellovac ABT) within a blood management protocol for reducing ABT requirements in consecutive SHF. METHODS The blood management protocol consisted of the applic...
Overexpression of the prosurvival Bcl-2 family members (Bcl-2, Bcl-xL, and Mcl-1) is commonly associated with tumor maintenance, progression, and chemoresistance. We previously reported the discovery of ABT-737, a potent, small-molecule Bcl-2 family protein inhibitor. A major limitation of ABT-737 is that it is not orally bioavailable, which would limit chronic single agent therapy and flexibil...
1-Aminobenzotriazole (1-ABT) is generally considered to be a nonselective mechanism-based inactivator of both human and non-human cytochrome P450 (P450) enzymes. Thus, 1-ABT is routinely used when conducting in vitro reaction phenotyping studies with new chemical entities in drug discovery to decipher P450 from non-P450-mediated metabolism. Experiments with pooled human liver microsomes (HLMs) ...
Our study aims to study the therapeutic effects of a novel Bcl-2 inhibitor, ABT-263, on hepatocellular carcinoma (HCC) and to provide primary preclinical data for future clinical trial with ABT-263. In this study we showed that Bcl-xL and survivin were up-regulated in HCC cell lines and human liver cancer tissues. Clinic used ABT-263 single treatment had no apoptotic effects on HCC cells wherea...
B-cell leukemia/lymphoma 2 (BCL-2) prevents commitment to programmed cell death at the mitochondrion. It remains a challenge to identify those tumors that are best treated by inhibition of BCL-2. Here, we demonstrate that acute myeloid leukemia (AML) cell lines, primary patient samples, and murine primary xenografts are very sensitive to treatment with the selective BCL-2 antagonist ABT-199. In...
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