The LIM domain protein Lmo2 and the basic helix-loop-helix transcription factor Scl/Tal1 are expressed in early haematopoietic and endothelial progenitors and interact with each other in haematopoietic cells. While loss-of-function studies have shown that Lmo2 and Scl/Tal1 are essential for haematopoiesis and angiogenic remodelling of the vasculature, gain-of-function studies have suggested an ...

Basic helix-loop-helix proteins, which are tissue specific (SCL) or broadly expressed (E proteins), interact positively to regulate erythroid specific genes. Here, expression of SCL and two broadly expressed E proteins, E47 and HEB, was high early in erythroid differentiation and declined during maturation. Stimulation of erythroid progenitors/precursors with stem cell factor (SCF) enhanced SCL...

We investigated the translational regulation of SCL protein expression and its role in hematopoietic lineage choice. We show that the expression of different SCL protein isoforms is regulated by signal transduction pathways that modulate translation initiation factor (eIF) function. A conserved small upstream open reading frame (uORF) in SCL transcripts acts as a cis-regulatory element for isof...

PURPOSE To investigate the lipid and DNA oxidative stress as well as corneal and retinal effects after ultraviolet B (UV-B) exposure in mice, with or without silicon hydrogel soft contact lenses (SCL). METHODS Twenty-eight C57BL6-strain male mice were divided into four groups: group I, control group with no SCL (SCL [-]) and no UV-B exposure (UV-B [-]); group II, senofilcon A SCL (senofilcon ...

This paper has two parts, on Baumslag–Solitar groups and on general G–trees. In the first part we establish bounds for stable commutator length (scl) in Baumslag–Solitar groups. For a certain class of elements, we further show that scl is computable and takes rational values. We also determine exactly which of these elements admit extremal surfaces. In the second part we establish a universal l...

In recent years, Structural Correspondence Learning (SCL) is becoming one of the most promising techniques for sentiment-transfer learning. However, SCL model treats each feature as well as each instance by an equivalent-weight strategy. To address the two issues effectively, we proposed a weighted SCL model (W-SCL), which weights the features as well as the instances. More specifically, W-SCL ...

Design for testability (DFT) refers to hardware design styles or it is an added hardware that reduces test generation complexity and test cost, also increases test quality. Sleep Convention Logic (SCL) is an asynchronous logic style which is based on Null Convention Logic (NCL). In the SCL the combinational blocks are made of threshold gates. SCL utilizes power gating method to further reduce t...

In this study, we examined the therapeutic potential of anti-Sclerostin Antibody (Scl-Ab) and bisphosphonate treatments for the bone fragility disorder Osteogenesis Imperfecta (OI). Mice with the Amish OI mutation (Col1a2 G610C mice) and control wild type littermates (WT) were treated from week 5 to week 9 of life with (1) saline (control), (2) zoledronic acid given 0.025mg/kg s.c. weekly (ZA),...

The transcription factors Scl and Lmo2 are crucial for development of all blood. An important early requirement for Scl in endothelial development has also been revealed recently in zebrafish embryos, supporting previous findings in scl(-/-) embryoid bodies. Scl depletion culminates most notably in failure of dorsal aorta formation, potentially revealing a role in the formation of hemogenic end...

SCL and LMO1 were both discovered by virtue of their activation by chromosomal translocation in patients with T-cell acute lymphoblastic leukemia (T-ALL). Overexpression of SCL and LMO1 in the thymus of transgenic mice leads to T-ALL at a young age. scid (severe combined immunodeficient) mice are unable to efficiently recombine antigen receptor genes and consequently display a developmental blo...