Tropical pyomyositis (TP) is an unusual infectious disease of skeletal muscles, caused by bacteria, and often associated with immunodeficiency conditions. The involvement of deep pelvic muscles, such as the iliac muscle, is even rarer. The association of systemic lupus erythematosus (SLE) and PT is seldom reported in the literature. Because SLE involves a state of immunosuppression resulting fr...

A case with the triad of pure red cell aplasia (PRCA), myasthenia gravis, and malignant thymoma is reported. There was a clonal proliferation of T cells within the thymoma, as demonstrated by a T cell antigen receptor (TCR) delta chain gene rearrangement. However, despite a large granular lymphocytosis, clonality could not be shown in the peripheral blood either before or after thymectomy. Ther...

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The human T-lymphotropic virus type 1 (HTLV-1) was the first human retrovirus identified. It has been clearly implicated in the pathogenesis of adult T-cell leukemia/lymphoma and myelopathy/tropical spastic paraparesis. Other infectious, inflammatory, or immune-related diseases (uveitis, infective dermatitis, polymyositis, arthropathy, Sjögren syndrome, interstitial lymphocytic pneumonia) are s...

We examined the effect of the human T lymphotropic virus type 1 (HTLVI) Tax gene product on the human transforming growth factor 01(TGF-01) promoter. Transfection ofdeleted constructs ofthe TGF-fl1 promoter revealed regions homologous with AP-1 binding sites that were required for Tax-induced transactivation of the TGF-(31 promoter. In addition, we examined the expression and secretion ofTGF-,3...

cystoisospora belli, formerly isospora belli , as an opportunistic infection agent, is seen in immunocompromised patients like htlv-1. we describe here cystoiso­sporiasis in an htlv1 iranian female in mashhad, northwestern iran in 2012 who presented with a debilitating diarrheal illness and great weight loss. c. belli was de­tected in her stool by modified acid-fast staining and then by molecul...

Background and aim: Adult T cell leukemia/lymphoma (ATLL) is an aggresive malignancy which may occur in human T lymphotropic virus1(HTLV1) infected persons. HTLV1 is endemic in Khorasan with prevalence of 2.3% in general population. Since specific cutaneous manifestations of lymphoma may occur in a significant number of patients, we studied ATLL patients in Mashhad.Mate...