The availability of large microarray data has brought along many challenges for biological data mining. Following Cheng and Church [4], many different biclustering methods have been widely used to find appropriate subsets of experimental conditions. Still no paper directly optimizes or bounds the Mean Squared Residue (MSR) originally suggested by Cheng and Church. Their algorithm, for a given e...

Considered an indicator of self-awareness, mirror self-recognition (MSR) has long seemed limited to humans and apes. In both phylogeny and human ontogeny, MSR is thought to correlate with higher forms of empathy and altruistic behavior. Apart from humans and apes, dolphins and elephants are also known for such capacities. After the recent discovery of MSR in dolphins (Tursiops truncatus), eleph...

Self-assembly of amyloid β-protein (Aβ) into toxic oligomers and fibrillar polymers is believed to cause Alzheimer's disease (AD). In the AD brain, a high percentage of Aβ contains Met-sulfoxide at position 35, though the role this modification plays in AD is not clear. Oxidation of Met(35) to sulfoxide has been reported to decrease the extent of Aβ assembly and neurotoxicity, whereas surprisin...

Recent work has shown that the efflux genes in Streptococcus pneumoniae that are responsible for acquired macrolide resistance can be distinguished as either mef(E) or mef(A). The genetic elements on which mef(A) and mef(E) are found also carry an open reading frame (ORF) that is 56% homologous to msr(A) in Staphylococcus. The prevalence of mef(A/E) and of the msr-like ORF [msr(D)] was evaluate...

Sustained activity of mammalian methionine synthase (MS) requires MS reductase (MSR), but there have been few studies of the interactions between these two proteins. In this study, recombinant human MS (hMS) and MSR (hMSR) were expressed in baculovirus-infected insect cells and purified to homogeneity. hMSR maintained hMS activity at a 1:1 stoichiometric ratio with a K(act) value of 71 nM. Esch...

Sir, The antibiotic resistance determinants Msr(A), MsrC and Msr(D) are all members of a group of ‘incomplete’ or Class 2 ABC transporters, characterized by the presence of two fused nucleotidebinding domains but lacking any identifiable transmembrane domains, and are typically involved in cellular processes other than transport. The msr(A) gene is carried on large staphylococcal plasmids, and ...

A meander stripline feed multiband microstrip antenna loaded with metasurface reflector (MSR) structure has been designed, analyzed and constructed that offers the wireless communication services for UHF/microwave RFID and WLAN/WiMAX applications. The proposed MSR assimilated antenna comprises planar straight forward design of circular shaped radiator with horizontal slots on it and 2D metasurf...

When formalizing security protocols, different specification languages support very different reasoning methodologies, whose results are not directly or easily comparable. Therefore, establishing clear relationships among different frameworks is highly desirable, as it permits various methodologies to cooperate by interpreting theoretical and practical results of one system in another. In this ...

The Mining Software Repositories (MSR) field analyzes the rich data available in source code repositories (SCR) to uncover interesting and actionable information about software system evolution. Major obstacles in MSR are the heterogeneity of software projects and the amount of data that is processed. Model-driven software engineering (MDSE) can deal with heterogeneity by abstraction as its cor...

Mechanical stress plays a key role in the development of cartilage degradation in osteoarthritis (OA). Nevertheless, the role of long noncoding RNAs in mechanical stress-induced regulation of chondrocytes remains unclear. The aim of this study was to explore the function of mechanical stress-related long noncoding RNAs in cartilage. Tissue samples were collected from 50 patients and chondrocyte...