While diffuse large-cell lymphoma (DLCL) is considered to be highly curable with current therapy, treatment failures are observed even with intensive combination chemotherapy regimens. In order to study the prognostic significance of actual dose intensity of chemotherapy in DLCL, we retrospectively analyzed 115 previously untreated patients treated as Stanford between 1975 and 1986 with cycloph...

BACKGROUND Diagnosis of obstructive sleep apnea syndrome (OSAS) by ambulatory systems is a growing practice in view of the large number of patients awaiting correct diagnosis. The Watch PAT100 (WP100) [Itamar Medical; Caesarea, Israel] is a portable device based on the peripheral arterial tone (PAT) signal, and is designed for unattended home sleep studies. OBJECTIVES To evaluate the efficacy...

• Regulated deficit irrigation was assessed in almond, peach and plum over 3 years. Fruit-growth slowdown stages are appropriate periods to apply irrigation. Peach yields were unaffected under a regulated of 75% ETC. 50% ETC maintained almond plum. Fruit quality improved </ListItem...

Clustering analysis is the problem of partitioning a set of objects O = {o1... on} into c self-similar subsets based on available data. In general, clustering of unlabeled data poses three major problems: 1) assessing cluster tendency, i.e., how many clusters to seek? 2) Partitioning the data into c meaningful groups, and 3) validating the c clusters that are discovered. We address the first pr...

OBJECTIVE To investigate the relation between measures of pain threshold and symptoms of distress to determine if fibromyalgia is a discrete construct/ disorder in the clinic. METHODS 627 patients seen at an outpatient rheumatology centre from 1993 to 1996 underwent tender point and dolorimetry examinations. All completed the assessment scales for fatigue, sleep disturbance, anxiety, depressi...

STUDY OBJECTIVES To assess the accuracy of a wrist-worn device (Watch_PAT 100) to diagnose obstructive sleep apnea in the home. DESIGN Participants completed 2 overnight diagnostic studies with the test device: 1 night in the laboratory with concurrent polysomnography and 1 night in the home with only the Watch_PAT. The order of the laboratory and home study nights was random. The frequency o...

The primary objective of a prospective study conducted over the July 1976-August 1977 period, as part of the joint project of the University of North Sumatra, Medan and the University of Amsterdam, was to determine the duration of prevention against hypovitaminosis A by 1 oral dose of 300,000 IU vitamin A. At 3-month intervals children were examined critically, fresh stool specimens were analy...

Climate change is one of the main challenges facing agricultural sector as it strives to meet global food needs. In arid and semiarid areas, scarcity water imposes use alternative sources - such reclaimed (RW) or desalinated (DW) deficit irrigation strategies, regulated (RDI), in order maintain productivity. The impact both RDI strategies on soil microbial communities conjunction with crop resp...

Recently, it has been reported that the relative dose intensity (RDI) of adjuvant chemotherapy (AC) influences survival in various cancers, but there are very few reports about RDI in pancreatic ductal adenocarcinoma (PDAC). The optimal timing for initiation of AC for PDAC also remains unknown. The aim of this study was to identify the significance of RDI and the time interval between surgery a...