Since multiple sclerosis (MS) is featured with widespread demyelination caused by autoimmune response, we investigated the recovery effects of F3.olig2 progenitors, established by transducing human neural stem cells (F3 NSCs) with Olig2 transcription factor, in myelin oligodendrocyte glycoprotein- (MOG-) induced experimental autoimmune encephalomyelitis (EAE) model mice. Six days after EAE indu...

Two experiments were conducted to test the hypothesis that higher formant normalization results from the auditory integration of F2 and F3 when they are within 3 Bark of each other. In the first experiment, Formants 3-5 were manipulated in both a "hid"-"head" continuum (in which F2 and F3 are within 3 Bark of each other) and a "hood"-"HUD" continuum (in which F2 and F3 are not within 3 Bark of ...

English /r/-/l/ perceptual training for Japanese speakers can improve production. However, it is unclear whether Japanese speakers actually improve their production of the primary acoustic cue for English /r/ and /l/, the third formant frequency (F3). The present study tested whether an English /r/-/l/ identification training program improves Japanese speakers’ production of these phonemes in t...

The purpose of this report is to test the hypothesis that speakers utilize an acoustic, rather than articulatory, planning space for speech production. It has been well-documented that many speakers of American English use different tongue configurations to produce /r/ in different phonetic contexts. The acoustic planning hypothesis suggests that although the lr/ configuration varies widely in ...

Differentiation therapy by induction of tumor cells is an important method in the treatment of hematological cancers such as leukemia. Tumor cell differentiation ends cancer cells' immortality, thus stopping cell growth and proliferation. In our previous study, we found that fucose-containing polysaccharide fraction F3 extracted from Ganoderma lucidum can bring about cytokine secretion and cell...

The distribution of the F3/F11 neuronal cell surface molecule was investigated in the developing and adult mouse cerebellum by immunocytochemistry at the light and electron microscopic levels. F3/F11 was confined to subsets of neuronal types, since the Purkinje cell body and dendritic arborization as well as the stellate cells were not immunoreactive. In the young developing cerebellum, the gra...

Pathotropic neural stem and/or progenitor cells (NSCs) can potentially deliver therapeutic agents to otherwise inaccessible cancers. In glioma, NSCs are found in close contact with tumor cells, raising the possibility that specificity of NSC contact with glioma targets originates in the tumor cells themselves. Alternatively, target preferences may originate, at least in part, in the tumor micro...