Column liquid chromatography (CLC) is a widely used unit operation in biotech and chemical process engineering for purification of target products (e.g. proteins for pharmaceutical agents) from unwanted substances. An aqueous solution containing the mixture of molecules is forced to flow through the chromatography column which is filled with porous particles (beads). While transport through the...

In this article, the development of high-order semi-implicit interpolation schemes for convection terms on unstructured grids is presented. It is based on weighted essentially non-oscillatory (WENO) reconstructions which can be applied to the evaluation of any field in finite volumes using its known cell-averaged values. Here, the algorithm handles convex cells in arbitrary three-dimensional me...

Multiphase flow in porous media provides a wide range of applications: from the environmental understanding (aquifer, site-pollution) to industrial process improvements (oil production, waste management). Modeling of such flows involves specific volume-averaged equations and therefore specific computational fluid dynamics (CFD) tools. In this work, we develop a toolbox for modeling multiphase f...

The present study gives a general outline for the fluid-dynamical calculation of flows at high pressure conditions. The main idea is to present a mathematical description of high pressure processes in liquids at compressible conditions, quantifying the effect of density variations on the flow pattern due to those pressure variations. The improved mathematical approach is coupled to a Large Eddy...

We present an integrated in-situ visualization approach for partitioned multi-physics simulation of fluid-structure interaction. The simulation itself is treated as a black box and only the information at the fluid-structure interface is considered, and communicated between the fluid and solid solvers with a separate coupling tool. The visualization of the interface data is performed in conjunc...