About 5-10% of patients with myasthenia gravis concomitantly have other autoimmune diseases. However, the coexistence of myasthenia gravis and pernicious anemia is rare. Here, we report a 73-year-old Taiwanese woman who developed myasthenia gravis 5 months after the onset of pernicious anemia. Her myasthenic and pernicious anemia symptoms markedly improved after pyridostigmine, prednisolone and...

BACKGROUND There are only rare reports of myasthenia gravis complicating human immunodeficiency virus infection. The role of immunomodulatory therapy is unknown. METHODS Case report and literature review. RESULTS The diagnosis of human immunodeficiency virus infection followed that of myasthenia gravis in a 35-year-old man. Clinical and electrophysiological features were diagnostic of gener...

introduction:yasthenia gravis is an autoimmune disorder resulting from a decreased number of active acetylcholine receptors at the neuromuscular junction. thymectomy is one of its current treatments. due to sensitivity of myasthenic patients to non-depolarizing muscle relaxants and also the interaction of this medication with anti-cholinestrase drugs, determining the dosage of non-depolarizing ...

The mechanisms that underlie the development and maintenance of autoimmunity in myasthenia gravis are poorly understood. In this investigation, we evaluate the role of survivin, a member of the inhibitor of apoptosis protein family, in humans and in two animal models. We identified survivin expression in cells with B lymphocyte and plasma cells markers, and in the thymuses of patients with myas...

Chronic Inflammatory Demyelinating Polyneuropathy is an autoimmune disease with progressive and relapsing courses. The main clinical presentations are diffuse deep tendon hyporeflexia or areflexia and symmetric proximal-distal muscles weakness. Myasthenia gravis is also an immune mediated disease with fluctuating ocular and bulbar symptoms and sometimes weakness. Although both myasthenia gravis...

Autoimmune myasthenia gravis is a T-cell-dependent, antibody-mediated, rare neuromuscular disorder. Interleukin-4, acting via interleukin-4 receptor alpha, plays a pivotal role in B-cell differentiation and antibody production and has been implicated to influence disease progression in experimental autoimmune myasthenia gravis. Polymorphisms of the interleukin-4 receptor alpha gene have been sh...

In 52 patients with myasthenia gravis serum myoglobin showed a significant inverse correlation to circulating thyroxine and triiodothyronine levels. The highest myoglobin concentration (240 ng/ml) was found in a myasthenia gravis patient with hypothyroidism. Slightly elevated myoglobin (54-60 ng/ml) was measured in four euthyroid myasthenic patients. The data suggest that a concomitant hypothyr...

The role of genetic factors in the causation of myasthenia gravis is not clear. Oppenheim, as early as 1900, reported familial instances of myasthenia and suggested that genetic factors were involved. On the other hand, Ford in 1937 stated, 'there is never any familial or hereditary tendency in myasthenia gravis'. However, since then, there have been several reports of familial instances of mya...

BACKGROUND Myasthenia gravis is an autoimmune neuromuscular disorder characterized by the production of abnormal autoantibodies directed against the receptors present in the neuromuscular junction. It has been the standard practice to offer thymectomy in all generalized myasthenia gravis patients despite the lack of robust evidence. OBJECTIVES The objectives of this study are to describe the ...

The ampicillin group of antibiotics has among been considered to be amongst the safest for use in patient with Myasthenia gravis, although a report in 1971 suggested that such might not be the case. A recent report suggested that ampidillin may aggravate Myasthenia gravis in patients and experimental animals. We report a case of clinically controlled Myasthenia gravis, in whom the administratio...