Pim-3, a proto-oncogene with serine/threonine kinase activity, is aberrantly expressed in malignant lesions, but not in normal tissues, of endoderm-derived organs, including the pancreas, liver, colon, and stomach. Furthermore, the development of hepatocellular carcinoma is accelerated in mice expressing Pim-3 transgene selectively in the liver when these mice are treated with a hepatocarcinoge...

Pim kinases, including Pim-1, Pim-2 and Pim-3, belong to a distinctive serine/threonine protein-kinase family. They are involved in cytokine-induced signal transduction and the development of lymphoid malignancies. Their kinase domains are highly homologous to one another, but share low sequence identity to other kinases. Specifically, there are two proline residues in the conserved hinge-regio...

ownload g a cell-based high-throughput screen designed to detect small chemical compounds that inhibit cell h and survival, we identified three structurally related compounds, 21A8, 21H7, and 65D4, with differactivity on cancer versus normal cells. Introduction of structural modifications yielded compound , which inhibits the proliferation of prostate cancer cell lines with IC50s of 0.6 to 0.9 ...

Downloa g a cell-based high-throughput screen designed to detect small chemical compounds that inhibit cell h and survival, we identified three structurally related compounds, 21A8, 21H7, and 65D4, with differactivity on cancer versus normal cells. Introduction of structural modifications yielded compound , which inhibits the proliferation of prostate cancer cell lines with IC50s of 0.6 to 0.9 ...

OBJECTIVE ATP-binding cassette transporter A1 (ABCA1) exerts an atheroprotective action through the biogenesis of high-density lipoprotein in hepatocytes and prevents the formation of foam cells from macrophages. Controlling ABCA1 is a rational approach to improving atherosclerotic cardiovascular disease. Although much is known about the regulatory mechanism of ABCA1 synthesis, the molecular me...

Pim-1 is a serine/threonine kinase as well as a proto-oncogene that induces T-cell lymphoma. Pim-1 induces cell cycle progression in cooperation with c-Myc and acts as an inhibitor of apoptotic cell death, actions that are involved in blood cell oncogenesis. However, little is known regarding the role of Pim-1 in oral carcinogenesis. We investigated Pim-1 expression in tongue squamous cell carc...

We previously observed that Pim-3 with serine/threonine kinase activity, was aberrantly expressed in malignant lesions of endoderm-derived organs, liver and pancreas. Because Pim-3 protein was not detected in normal colon mucosal tissues, we evaluated Pim-3 expression in malignant lesions of human colon, another endoderm-derived organ. Pim-3 was detected immunohistochemically in well-differenti...

In this paper we study the properties of protocol independent multicast (PIM) in non-strictly hierarchical network environments. In particular, we investigate the cost (overhead) behaviour of the PIM protocols i.e., sparse mode (PIM-SM), dense mode with flood and prune mechanism (PIM-DMFP), dense mode with state refresh (PIM-DMSR), and source specific multicast (PIM-SSM). By assuming that the l...

Studies of SOCS-1-deficient mice have implicated Socs-1 in the suppression of JAK-STAT (Janus tyrosine kinase-signal transducers and activators of transcription) signaling and T cell development. It has been suggested that the levels of Socs-1 protein may be regulated through the proteasome pathway. Here we show that Socs-1 interacts with members of the Pim family of serine/threonine kinases in...

Rationale: Cardioprotective effects of Pim-1 kinase have been previously reported but the underlying mechanistic basis may involve a combination of cellular and molecular mechanisms that remain unresolved. The elucidation of the mechanistic basis for Pim-1 mediated cardioprotection provides important insights for designing therapeutic interventional strategies to treat heart disease. Objective:...