Aim . To study the possible synergistic action of steroid hormones and hormone-specific autoantibodies anti-autoantibodies in conversion ER+/PR+ tumors into ER-/PR- breast cancer patients. Materials Methods Concentrations estradiol (E2) progesterone (Pg) levels idiotypic IgA antibodies (IgA 1 -E2 -Pg) as well anti-idiotypic IgG (IgG 2 were studied serum 979 patients (432 with stage 547 stages 2...

Let G be a graph with vertex set V(G) and edge E(G), let d(u,w) denote the length of u−w geodesic in G. For any v∈V(G) e=xy∈E(G), d(e,v)=min{d(x,v),d(y,v)}. distinct edges e1,e2∈E(G), R{e1,e2}={z∈V(G):d(z,e1)≠d(z,e2)}. Kelenc, Tratnik Yero [Discrete Appl. Math. 251 (2018) 204-220] introduced notion an resolving dimension graph: A subset S⊆V(G) is if |S∩R{e1,e2}|≥1 for dimension, edim(G), minimu...

Studies have shown that estradiol-17β (E2) regulates gonadotropin-releasing hormone (GnRH) and GnRH receptor expression in hypothalamus and pituitary. Several studies have shown that GnRH and its receptor are also expressed in peripheral reproductive organs and little is known about their regulations. In this study, GnRH and GnRH receptor structures, functions, their peripheral expressions and ...

In this paper we study Cohen-Macaulay local rings of dimension d, multiplicity e and second Hilbert coefficient e2 in the case e2=e1−e+1. Let h=μ(m)−d. If e2≠0 then our can prove that type(A)≥e−h−1. type(A)=e−h−1 show associated graded ring G(A) is Cohen-Macaulay. next when type(A)=e−h determine all possible series A. depthG(A) completely determines Series

conclusions this study provided conserved b-cell epitopes and peptides that can be useful for designing entry inhibitors and vaccines able to cover a global population, especially where genotype 5a is common. results differences in the probability of glycosylation in e1 and e2 regions were observed in this study. three conserved antigenic b-cell epitopes were predicted in the e2 regions and als...

هدف اصلی این پژوهش ارائه چارچوبی برای ارزیابی عملکرد شرکت بهره‌­برداری قطار شهری مشهد بر مبنای کارت امتیازی متوازن و تکنیک تصمیم‌­گیری چندمعیاره (بهترین ـ بدترین فازی) است. حاضر از نظر هدف، کاربردی روش، کمّی اسنادی جمع‌­آوری داده‌های کیفی اساس 15 خبره در طی مقطع زمانی بین سال­‌های 1396 تا 1398 صورت پذیرفت. 9 معیار منظر مالی، 16 مشتریان، 8 فرایند داخلی 14 رشد توسعه یادگیری طریق اسناد پژوهش­‌های پ...

Abstract Ubiquitination is an important modification process in eukaryotic organisms, and ubiquitin ligase (E3) the most diversified component of this system. APIP6 (AvrPiz-t interacting protein 6) one E3s rice, involved recognition AvrPiz-t, effector from pathogen Magnaporthe oryzae , for initiation host defense against M. . However, structural detail how performs its function remains elusive....