statement of the problem: recurrent aphthous stomatitis (ras) is one of the most common lesions in the oral cavity. due to its multifactorial nature, there is no definitive treatment for ras. laser therapy is one of the suggested treatments to reduce patient’s discomfort. purpose: the purpose of the present clinical trial is to assess the effect of low and high level laser therapy on pain contr...

Background: Ovarian carcinoma is one of the leading causes of cancer-related death among females. K-ras codon 12 mutations are commonly occurring mutations in different types of cancers and leads to resistance against anti-EGFR therapeutics. Hence, determination of mutations in k-ras gene is crucial for predicting response to anti-EGFR therapies. This study aimed to evaluate the prevalence of k...

The study investigated whether there was any significant generic difference between the Research Questions (RQs) and Method sections of applied linguistics research articles (RAs) published in international and local Iranian journals. Two hundred applied linguistics RAs (100 from each group) were selected from 5 SSCI-indexed international journals and 5 Iranian Scientific-Research (Elmi-Pazhouh...

statement of problem: recurrent aphthous stomatitis (ras) is one of the most common diseases affecting the oral mucosa. many topical and systemic medications used to treat ras have adverse local and systemic effects. chamomill (kamillosan) has been shown to be an effective drug, without any noticeable side effects. purpose: the aim of present study was to assess the efficacy of a chamomill mout...

Human cells contain four homologous Ras proteins, but it is unknown whether these homologues have different biological functions. As a first step in determining if Ras homologues might participate in distinct signaling cascades, we assessed whether a given Ras guanine nucleotide exchange factor could selectively activate a single Ras homologue in vivo. We found that Ras-GRF/Cdc25Mm activates Ha...

The Ras(17N) dominant negative antagonizes endogenous Ras function by forming stable, inactive complexes with Ras guanine nucleotide exchange factors (GEFs; e.g., SOS1). We have used the growth-inhibitory phenotype of Ras(17N) to characterize two aspects of Ras interaction with GEFs. First, we used a nonprenylated version of Ras(17N), designated Ras(17N/186S), which no longer associates with th...