We isolated a novel yeast α-COP mutant, ret1-3, in which α-COP is degraded after cells are shifted to a restrictive temperature. ret1-3 cells cease growth at 28°C and accumulate the ER precursor of carboxypeptidase Y (p1CPY). In a screen for high copy suppressors of these defects, we isolated the previously unidentified yeast ε-COP gene. ε-COP (Sec28p) overproduction suppresses the defects of r...

The synthetic amino acid copolymer copolymer 1 (Cop 1) suppresses experimental autoimmune encephalomyelitis (EAE) and is beneficial in multiple sclerosis. To further understand Cop 1 suppressive activity, we studied the cytokine secretion profile of various Cop 1-induced T cell lines and clones. Unlike T cell lines induced by myelin basic protein (MBP), which secreted either T cell helper type ...

The purpose of the present study was to describe the spatial-temporal parameters of the centre of pressure (COP) trajectory during the single-support phase of gait among stroke survivors and relate these parameters to the severity of sensorimotor impairment. Fifty-seven participants were asked to walk at their preferred and fast speed over a pressure sensitive mat. Outcome measures included ant...

Knowledge of the center of pressure (COP) trajectory during stance can elucidate possible foot pathology, provide comparative effectiveness of foot orthotics, and allow for appropriate calculation of balance control and joint kinetics during gait. Therefore, the goal of this study was to investigate the COP movement when walking at self-selected speeds with plantigrade, equinus, inverted, and e...

Protein, or colloid, osmotic pressure (COP) is of sufficient magnitude to exert a powerful effect on Starling forces across the capillary wall. Although avian skin lacks active mechanisms for fluid transmission, such as sweating, it is now hypothesized that passive oncotic forces may regulate fluid flow and distribution in the skin and related phenomena. In this study, serum protein profiles, a...

In the classical cop and robber game, two players, the cop C and the robber R, move alternatively along edges of a finite graph G = (V,E). The cop captures the robber if both players are on the same vertex at the same moment of time. A graph G is called cop win if the cop always captures the robber after a finite number of steps. Nowakowski, Winkler (1983) and Quilliot (1983) characterized the ...

This study aimed to investigate the relationship between the muscular strength of the lower extremity in a load side and the characteristics of center of foot pressure (COP) during landing after crossover stepping in the elderly. The study population comprised 8 elderly subjects (average age, 75.8+/-8.0 years) and 9 young individuals (average age, 21.6+/-2.5 years). Using a separation-type forc...

We have previously isolated ε-COP, the α-COP interactor in COPI of Aspergillus nidulans, by yeast two-hybrid screening. To understand the function of ε-COP, the aneA (+) gene for ε-COP/AneA was deleted by homologous recombination using a gene-specific disruption cassette. Deletion of the ε-COP gene showed no detectable changes in vegetative growth or asexual development, but resulted in decreas...

BACKGROUND Carbon monoxide poisoning (COP) often produces severe complications and can be fatal. Because this topic has not been well delineated, we investigated long-term prognoses of patients with COP (COP[+]). METHODS In this retrospective nationwide cohort study, 441 COP[+] patients and 8820 COP[-] controls (120) from 1999 to 2010 were selected from Taiwan's National Health Insurance Rese...