All-trans retinoic acid (tRA) and arsenic trioxide (As(2)O(3)) induce non-cross-resistant complete clinical remission in patients with acute promyelocytic leukemia with t(15;17) translocation and target PML-RARalpha, the leukemogenic protein, by different pathways suggesting a possible therapeutic synergism. To evaluate this possibility, this study examined the effect of As(2)O(3) on tRA-induce...

ÐIn this paper, the Dynamic Trac Routing problem is de®ned as the real-time point diversion of trac during non-recurrent congestion. This dynamic trac routing problem is then formulated as a feedback control problem that determines the time-dependent split parameters at the diversion point for routing the incoming trac ̄ow onto the alternate routes in order to achieve a user-equilibrium tra...

Ten mutations are described that transform genotypic hermaphrodites of the nematode Caenorhabditis elegans into phenotypic males. These fall into three autosomal complementation groups, termed tra-1, tra-2, and tra-3. Two alleles of tra-1 produce almost complete transformation, to a fertile male phenotype; such transformed animals are useful for analyzing sex-linked genes. All alleles of tra-1 ...

Title of Document: ISOLATION AND CHARACTERIZATION OF CAENORHABDITIS BRIGGSAE TRA MUTANTS. Danielle Fay Kelleher, Master of Science, 2005 Directed By: Professor Eric S. Haag Department of Biology In order to aid in the reconstruction of the Caenorhabditis briggsae sex determination pathway, for the purposes of studying the convergent evolution of hermaphroditism and mating system change in nemat...

The Caenorhabditis elegans sex-determination gene, tra-2, is translationally regulated by two 28 nt elements (DREs) located in the 3'UTR that bind a factor called DRF. This regulation requires the laf-1 gene activity. We demonstrate that the nematode Caenorhabditis briggsae tra-2 gene and the human oncogene GLI are translationally regulated by elements that are functionally equivalent to DREs. ...

In analogy to the ow of uids, it is expected that the aggregate density and the velocity of vehicles in a section of a freeway adequately describe the tra c ow dynamics. The conservation of mass equation together with the aggregation of the vehicle following dynamics of controlled vehicles describes the evolution of the tra c density and the aggregate speed of a tra c ow. There are two kinds of...

Assume T is superstable and small. Using the multiplicity rankM we find locally modular types in the same manner as U -rank considerations yield regular types. We define local versions of M-rank, which also yield meager types. 0. Introduction. Throughout, T is superstable, small, and we work in C = C. In [Ne1] we defined the multiplicity rank M and proved that M has additivity properties simila...

Caenorhabditis elegans and Caenorhabditis briggsae are both self-fertile hermaphroditic nematodes that evolved independently from male/female ancestors. In C. elegans, FEM-1, FEM-2, and FEM-3 specify male fates by promoting proteolysis of the male-repressing transcription factor, TRA-1. Phenotypes of tra-1 and fem mutants are consistent with this simple linear model in the soma, but not in the ...

The Available Bit Rate (ABR) service has been shown to enable persistent, greedy data sources to e ciently utilize ATM network resources. However, the throughput for bursty TCP over ABR data tra c in the presence of interfering tra c may not be as good as for persistent ABR sources without interfering tra c. This paper shows that in a comparison of rate based ABR schemes (EPRCA and ERICA) and a...

All-trans retinoic acid (tRA)-induced differentiation in NB4 cells, a cell line derived from an acute promyelocytic leukemia patient with t(15;17) translocation, is markedly facilitated by sodium butyrate (NaB), a histone deacetylase inhibitor (HDACI), or by hexamethylene bisacetamide (HMBA), a non-HDACI tRA-differentiation inducer, as determined by nitroblue tetrazolium reduction. The tRA-indu...