نتایج جستجو برای: مدل tam
تعداد نتایج: 126565 فیلتر نتایج به سال:
Tamoxifen (TAM) is a selective estrogen receptor modulator widely used in the prevention and treatment of breast cancer. A major mode of metabolism of the major active metabolites of TAM, 4-OH-TAM and endoxifen, is by glucuronidation via the UDP-glucuronosyltransferase (UGT) family of enzymes. To examine whether polymorphisms in the UGT enzymes responsible for the glucuronidation of active TAM ...
مقدمه: مدارک پزشکی الکترونیکی، یکی از فناوریهای نوین برای بهرهبرداری از اطلاعات سلامت است که به عنوان سیستمی با ارزش جهت دسترسی به اطلاعات بیمار در بیمارستانها شناخته شده است و برای اجرای موفق آن مانند هر سیستم دیگری باید در ابتدا فاکتورهای مؤثر بر پذیرش و استفاده از آن را سنجید. هدف از این مطالعه بررسی نظام مند مقالات منتشر شده درباره عوامل مؤثر بر پذیرش مدارک پزشکی الکترونیکی براساس تئوری...
مقدمه: مدارک پزشکی الکترونیکی، یکی از فناوریهای نوین برای بهرهبرداری از اطلاعات سلامت است که به عنوان سیستمی با ارزش جهت دسترسی به اطلاعات بیمار در بیمارستانها شناخته شده است و برای اجرای موفق آن مانند هر سیستم دیگری باید در ابتدا فاکتورهای مؤثر بر پذیرش و استفاده از آن را سنجید. هدف از این مطالعه بررسی نظام مند مقالات منتشر شده درباره عوامل مؤثر بر پذیرش مدارک پزشکی الکترونیکی براساس تئوری...
Tamoxifen (TAM), used as the endocrine therapy of choice for breast cancer, undergoes metabolism primarily forming N-desmethyltamoxifen, 4-hydroxytamoxifen, alpha-hydroxytamoxifen, and tamoxifen-N-oxide (TNO). Our earlier studies demonstrated that flavin-containing monooxygenases (FMOs) catalyze the formation of TNO. The current study demonstrates that human FMO1 and FMO3 catalyze TAM N-oxidati...
PURPOSE Tamoxifen (Tam) is the most prescribed hormonal agent for treatment of estrogen receptor α (ERα)-positive breast cancer patients. Using microarray analysis, we observed that metastatic breast tumors resistant to Tam therapy had elevated levels of Dicer. EXPERIMENTAL DESIGN We overexpressed Dicer in ERα-positive MCF-7 human breast cancer cells and observed a concomitant increase in exp...
Generally speaking, technology acceptance model (TAM, Davis, et al., 1989; Davis, 1989) is a successful model and prior studies have explored the TAM from different perspectives and many antecedents have been identified. However, the overview of TAM shows that the explanatory power of TAM is limited. Furthermore, more and more inconsistencies in results appeared along with the development of TA...
To assess the effects of chronic administration of tamoxifen (TAM) and toremifene (TOR) on genetic damage related to carcinogenesis, we measured DNA adduct formation by (32)P-postlabeling in liver, kidney, and uterus of Fischer rats given TAM or TOR in the diet for 18 months. TAM induced high levels of DNA adducts in the liver in a dose-dependent manner. The total adduct levels were 3000 +/- 87...
The goals of this clinical trial involving postmenopausal women with metastatic breast cancer were to: (a) examine the effects of letrozole on tamoxifen (TAM) pharmacokinetics; (b) examine estrogen suppression in patients receiving TAM plus letrozole; and (c) evaluate tolerability, toxicity, objective response, and time to progression for the combination. Postmenopausal women with measurable or...
BACKGROUND Tamoxifen (TAM) is generally considered the hormonal agent of choice for postmenopausal women with hormone receptor positive breast carcinoma. The somatostatin analogues, including octreotide, have demonstrated inhibition of breast carcinoma cell lines and multiple endocrinologic actions, including reduction of insulin-like growth factor I (IGF-I), a potent mitogen for breast carcino...
PURPOSE Combination estrogen + progestin therapy has been associated with increased breast cancer risk in postmenopausal women. Selective estrogen receptor modulators (SERM) are potential alternatives to progestins, although the endometrial safety of estrogen + SERM co-therapies is not known. The goal of this study was to evaluate the endometrial profile of low-dose estradiol and the SERM tamox...
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