Previous studies demonstrated that during cisplatin-induced acute renal failure, there is a significant reduction in proximal tubule fatty acid oxidation. We now report on the effects of peroxisome proliferator-activated receptor-alpha (PPAR alpha) ligand Wy-14643 (WY) on the abnormalities of medium chain fatty acid oxidation and pyruvate dehydrogenase complex (PDC) activity in kidney tissue of...

OBJECTIVE The aim of this study was to develop and validate a scoring system for bowel dysfunction after low anterior resection (LAR) for rectal cancer, on the basis of symptoms and impact on quality of life (QoL). BACKGROUND LAR for rectal cancer often results in severe bowel dysfunction (LAR syndrome [LARS]) with incontinence, urgency, and frequent bowel movements. Several studies have inve...

Hypolipidemic compound pirinixic acid (WY-14643, WY) is known to exert pleiotropic (other than primary) effects, such as activation of peroxisome proliferator-activated receptors (PPAR-alpha), transcription factors regulating different cardiac functions. Their role in ischemia-reperfusion (I/R) injury and cardioprotection is less clear, although protective effects of PPAR agonists have been doc...

Chronic exposure to peroxisome proliferators (PPs) leads to increased incidence of liver tumors in rodents. Liver tumor induction is thought to require increased hepatocyte proliferation and suppression of apoptosis. Transcript profiling showed increased expression of proapoptotic genes and decreased expression of antiapoptotic genes in the livers of mice exposed to the PP WY-14,643 (WY). We te...

Acute lung injury (ALI) still represents a major cause of morbidity and mortality in intensive care units. Beneficial effects have been described after activation of the peroxisome proliferator-activated receptor (PPAR)-alpha by fibrates such as WY 14,643 (WY) in inflammatory models. In the present study, the impact of WY was investigated in a model of endotoxin (lipopolysaccharide; LPS)-induce...

0022-1694/$ see front matter 2012 Elsevier B.V. A http://dx.doi.org/10.1016/j.jhydrol.2012.12.020 ⇑ Corresponding author. Address: State Key Lab. of Research Center for Eco-Environmental Sciences, Ch Ecology Building RM301, 18 Shuangqing Rd., Beijing 1 62849102. E-mail address: [email protected] (N. Lu). China is facing a growing water crisis due to climate and land use change, and rise in huma...

Peroxisome proliferators (PP) are known hepatocarcinogens in rats and mice. We have investigated the ability of Wyeth-14 643 (Wy), a PP and potent rodent carcinogen, to induce replicative DNA synthesis and to modulate the levels of peroxisome proliferator activated receptor-alpha (PPAR alpha) transcriptionally-dependent genes in primary rat hepatocyte (HPC) cultures and hepatocyte/nonparenchyma...

Prosopolepis Lutz is validated as a monotypic subgenus of Wyeomyia Theobald and the type species, Weomyia confusa (Lutz), is redescribed. The description includes illustrations of the male and female genitalia, the 4th-stage larva, and the pupa. Prosopolepis Jiui Bonne-Wepster and Bonne is resurrected from synonymy with Wy. confisa and recognized as the senior synonym of Wyeomyia kerri de1 Pont...

1 Wy dział Re ha bi li ta cji, Aka de mia Wy cho wa nia Fi zycz ne go Jó ze fa Pił sud skie go, War sza wa 2 Od dział Re ha bi li ta cji, Szpi tal Pra ski, War sza wa 3 Za kład Sta ty sty ki i In for ma ty ki, Aka de mia Wy cho wa nia Fi zycz ne go Jó ze fa Pił sud skie go, War sza wa 1 Department of Rehabilitation, the Jozef Piłsudski University of Physical Education, Warsaw 1 Department of Re...