Myxococcus xanthus is a bacterium that undergoes multicellular development. C-signaling influences gene expression and movement of cells into aggregates. Expression of the dev operon, which includes genes essential for efficient sporulation, depends in part on C-signaling and reaches its highest level in cells within aggregates, ensuring that spores form within fruiting bodies. Here, an upstrea...

The importance of ADA (adenosine deaminase) in the immune system and the role of its interaction with an ADA-binding cell membrane protein dipeptidyl peptidase IV (DPPIV), identical to the activated immune cell antigen, CD26, has attracted the interest of researchers for many years. To investigate the specific properties in the structure-function relationship of the ADA/DPPIV-CD26 complex, its ...

L atent autoimmune diabetes in adults (LADA) is a term used to describe a form of autoimmune diabetes that resembles type 1 diabetes, but has a later onset and slower progression toward an absolute insulin requirement. Controversies have been surrounding this concept and several attempts have been made to better characterize and classify it. But LADA still remains poorly understood and defined ...

Corresponding author: Byung Wan Lee Department of Internal Medicine, Yonsei University College of Medicine, 50 Yonsei-ro, Seodaemun-gu, Seoul 120-752, Korea E-mail: [email protected] Type 1 diabetes (T1D) is caused by interactions of genetic predisposition, immunologic triggers, and environmental events leading to autoimmune-mediated pancreatic β-cell destruction and insulin deficiency, although ...

Here, we describe a novel presentation of latent autoimmune diabetes in adults (LADA) involving a deterioration of glycemic control in a patient after bariatric surgery. A 43-year-old woman with a 7-year diagnosis of type 2 diabetes (T2D), treated initially with metformin and then also insulin glargine 2 years later, and a background of hypothyroidism and vitiligo was referred for bariatric sur...

Latent autoimmune diabetes of adults (LADA) is a subset of type 1 diabetes. The disease accounts for;2–12% of all cases of diabetes (1). The pathogenesis of the disease involves autoimmune destruction of the b-cells of the pancreatic islet that produce insulin. There is a cellmediated effect, via islet-reactive T cells (2), and a humoral immune response via autoantibodies (3). Studies have indi...

Lada merupakan tanaman rempah yang populer di dunia, memiliki prospek pasar sangat bagus sehingga komoditi lada cukup menjanjikan apabila usaha budidayanya dapat dikembangkan. Untuk memperoleh bibit dilakukan perbanyakan secara vegetatif dengan cara setek. Namun setek kendala mana akarnya sulit muncul tingkat keberhasilannya rendah, untuk merangsang terbentuknya akar dan mempercepat pertumbuhan...

This 3-year prospective study enrolled 95 subjects from15 Chinese cities including 25 high-titer (GADA ‡180 units/mL) LADA patients, 42 low-titer (GADA <180 units/mL) LADA patients, and 28 type 2 diabetic patients, the latter two groups as controls of similar age, sex, andBMI. Clinical characteristicswere determined annually, including glycosylated hemoglobin (HbA1c), fasting C-peptide (FCP), a...

BACKGROUND The study of endogenous insulin secretion may provide relevant insight into the comparison of the natural history of adult onset latent autoimmune diabetes (LADA) with types 1 and 2 diabetes mellitus. The aim of this study was to compare the results of the C-peptide response to mixed-meal stimulation in LADA patients with different disease durations and subjects with type 2 and adult...

Latent autoimmune diabetes in adults (LADA) is an autoimmune diabetes of adult-onset with the presence of diabetes associated autoantibodies. Familial renal glucosuria (FRG) is an inherited renal tubular disorder that causes persistent isolated glucosuria in the absence of hyperglycemia. We report a novel case of LADA and certain FRG. A 44-year-old man was admitted to our hospital for uncontrol...