In this study we show that high molecular weight kininogen (HK) inhibited alpha-thrombin-induced aggregation of human platelets in a dose-dependent manner with complete inhibition occurring at plasma concentration (0.67 mumol/L) of HK. HK (0.67 mumol/L) also completely inhibited thrombin-induced cleavage of aggregin (Mr = 100 Kd), a surface membrane protein that mediates adenosine diphosphate (...

abstract the whole blood potassium concentration has shown the bimodal distribution in sheep, which has been classified into lk and hk types; hk allele is recessive to lk with a single gene inheritance. this polymorphism showed different behavior in different environment, which could be due to adaptation process. this research was conducted on the zel and kermani breed research station, which k...

Within the normal human epidermis only Langerhans and indeterminate cells express HLA-DR. Human keratinocytes (HK), however, may also express HLA-DR in certain disease states characterized by mononuclear cell infiltrates. Previous studies have shown that HK synthesize HLA-DR in response to stimulation by interferon gamma (INF-gamma). The purposes of this study were to define conditions under wh...

Codina, Juan, Jian Li, and Thomas D. DuBose, Jr. CD63 interacts with the carboxy terminus of the colonic H -K -ATPase to increase plasma membrane localization and Rb uptake. Am J Physiol Cell Physiol 288: C1279–C1286, 2005. First published January 12, 2005; doi:10.1152/ajpcell.00463.2004.—The carboxy terminus (CT) of the colonic H -K -ATPase is required for stable assembly with the -subunit, tr...

Hexokinase is responsible for glucose phosphorylation, a process fundamental to regulating glucose uptake. In some tissues, hexokinase translocates to the mitochondria, thereby increasing its efficiency and decreasing its susceptibility to product inhibition. It may also decrease free radical formation in the mitochondria and prevent apoptosis. Whether hexokinase translocation occurs in the hea...

OBJECTIVE The purpose of this article is to analyze the expression of Glut-1 and HK-II, the association between their expression and 18F-FDG accumulation in pancreatic cancer. METHODS Fifty patients with histologically proven pancreatic cancer were included in this preliminary study, all of whom received 18F-FDG PET/CT performance before surgery. Immunohistochemical staining of tumor tissue a...

Objective: To study the antianaphylactic, antihistaminic and mast cell stabilization activity of Bresol (HK-07) in experimental animals. Materials and Methods: Experimental studies of Bresol (HK-07) were evaluated using Wistar rats and Duncan Hartley guinea pigs. The antianaphylactic activity of Bresol (HK-07) was investigated in rats using active anaphylaxis model. The effect of Bresol (HK-07)...

The present study compared the efficacy of ACTH 4-9 analog, methylphenidate, and placebo on attention deficit disorder with 30 (HK) children with attention deficit disorder and psychometric measurements. HK children were randomly placed into three groups, according to body weight, and treated with placebo, methylphenidate, and adrenocorticotropic hormone fractions (ACTH 4-9 analog). The results...

Amaç: Kanser hücrelerinin glikoza duydukları ihtiyaç sonucu solunumla ilgili metabolik yolaklarını yeniden düzenlemesi, kanser hücrelerini normal hücrelerden ayıran önemli değişimlerden biridir ve bu değişim ilk olarak 1920’li yıllarda Otto Warburg tarafından rapor edildiği için “Warburg Fenomeni” bilinir. hücrelerindeki artmış glikoliz, yolağı bir hedefi haline getirir. Glikolizin hız kısıtlay...

BACKGROUND Angioedema without wheals (AE) is a symptom characterised by localised episodes of oedema presumably caused by kinin release from kininogen cleavage. It can result from a hereditary deficiency in C1 Inhibitor (C1Inh), but it can present with normal level of C1Inh. These forms are typically difficult to diagnose although enhanced kinin production is suspected or demonstrated in some c...