Axonal insult induces retinal ganglion cell (RGC) death through a BAX-dependent process. The pro-apoptotic Bcl-2 family member BIM is known to induce BAX activation. BIM expression increased in RGCs after axonal injury and its induction was dependent on JUN. Partial and complete Bim deficiency delayed RGC death after mechanical optic nerve injury. However, in a mouse model of glaucoma, DBA/2J m...

In the past few years, the pro-apoptotic molecule Bim has attracted increasing attention as a plausible target for tumor therapy. A variety of normal and pathological systems regulated by Bim, dependent on cell type, apoptotic stimulation, and chemotherapeutic agents, have been documented. Bim promotes anoikis of many tumor cells, such as lung cancer, breast cancer, osteosarcoma, and melanoma. ...

̶ Implementation of BIM in the construction industry relies on sufficient knowledge and skills about BIM in order to gain momentum and success. Thorough understanding of the possibilities as well as challenges related to the application of BIM constitutes essential drivers for the adoption of BIM among all the industry actors throughout the construction process. Thus, there is a need for supply ...

Construction education needs to embrace the opportunities and overcome the challenges presented by Building Information Modeling (BIM) to remain current and relevant. Although a growing number of university architecture, engineering and construction (AEC) programs have begun to offer courses that include BIM content, few programs have strategies in place to fully integrate BIM across curriculum...

The BH3-only Bim protein is a major determinant for initiating the intrinsic apoptotic pathway under both physiological and pathophysiological conditions. Tight regulation of its expression and activity at the transcriptional, translational and post-translational levels together with the induction of alternatively spliced isoforms with different pro-apoptotic potential, ensure timely activation...

BIM is a modeling technology that allows architects and builders to visually create, analyze, and share building models. BIM is gaining a growing importance which may be reflected in the increasing number of owners who demand BIM use. However, despite the perceived uptick in demand for BIM, an industry wide adoption has not yet been reached. Likewise, the adoption of BIM enhanced business pract...

Human T-cell leukemia virus type 1 (HTLV-1), an etiological agent of adult T-cell leukemia, immortalizes and transforms primary human T cells in vitro in both an interleukin (IL)-2-dependent and IL-2-independent manner. Expression of the HTLV-1 oncoprotein Tax transforms the growth of the mouse T-cell line CTLL-2 from being IL-2-dependent to IL-2-independent. Withdrawal of IL-2 from normal acti...

This paper reviews BIM concepts, with a particular focus on its applicability and uptake within the business processes in the construction industry. An exploratory study is being carried out to examine the current state of BIM practices using the instrument of survey questionnaire and literature review. The partial findings from an on-going survey show that, the inevitable need for organisation...