نتایج جستجو برای: مخازن cng

تعداد نتایج: 5181  

Journal: :The Journal of General Physiology 2000
Elena Molokanova Alexei Savchenko Richard H. Kramer

The cGMP sensitivity of cyclic nucleotide-gated (CNG) channels can be modulated by changes in phosphorylation catalyzed by protein tyrosine kinases (PTKs) and protein tyrosine phosphatases. Previously, we used genistein, a PTK inhibitor, to probe the interaction between PTKs and homomeric channels comprised of alpha subunits (RETalpha) of rod photoreceptor CNG channels expressed in Xenopus oocy...

2013
Lei Zhou Diomedes E. Logothetis

403 C o m m e n t a r y In this issue, Dai et al. present an investigation of the biophysics of phosphatidylinositide (PIP) regulation of the cyclic-nucleotide gated (CNG) channels expressed in cone photoreceptors. Although PIPs facilitate or stabilize the activation of many other types of ion channels , they strongly inhibit the response to cAMP or cGMP (collectively, cNMP) of CNG channels. Pr...

 استفاده از گاز طبیعی فشرده به عنوان سوختی پاک در سراسر دنیا در حال افزایش است. با رشد روزافزون وسایل نقلیه در ایران و به دلیل بالابودن هزینه­های احداث جایگاه­های CNG، مکان­یابی مناسب و بهینه این جایگاه­ها از اهمیت ویژه‌ای برخوردار است. مدل مکان­یابی جریان سوخت­گیری یکی از مدل­هایی است که اخیراً به منظور مکان­یابی جایگاه­های سوخت مطرح­ شده است. در این تحقیق جایگاه­های سوخت CNG در دو مسیر برون­شه...

Journal: :Clinical cancer research : an official journal of the American Association for Cancer Research 2015
Friederike Göke Alina Franzen Trista K Hinz Lindsay A Marek Petros Yoon Rakesh Sharma Maike Bode Anne von Maessenhausen Brigitte Lankat-Buttgereit Antonia Göke Carsten Golletz Robert Kirsten Diana Boehm Wenzel Vogel Emily K Kleczko Justin R Eagles Fred R Hirsch Tobias Van Bremen Friedrich Bootz Andreas Schroeck Jihye Kim Aik-Choon Tan Antonio Jimeno Lynn E Heasley Sven Perner

PURPOSE FGFR1 copy-number gain (CNG) occurs in head and neck squamous cell cancers (HNSCC) and is used for patient selection in FGFR-specific inhibitor clinical trials. This study explores FGFR1 mRNA and protein levels in HNSCC cell lines, primary tumors, and patient-derived xenografts (PDX) as predictors of sensitivity to the FGFR inhibitor, NVP-BGJ398. EXPERIMENTAL DESIGN FGFR1 status, expr...

Journal: :Proceedings. Biological sciences 2010
David C Plachetzki Caitlin R Fong Todd H Oakley

The evolutionary histories of complex traits are complicated because such traits are comprised of multiple integrated and interacting components, which may have different individual histories. Phylogenetic studies of complex trait evolution often do not take this into account, instead focusing only on the history of whole, integrated traits; for example, mapping eyes as simply present or absent...

Journal: :The Journal of neuroscience : the official journal of the Society for Neuroscience 2000
A Gerstner X Zong F Hofmann M Biel

Cyclic nucleotide-gated (CNG) channels play a key role in olfactory and visual transduction. Native CNG channels are heteromeric complexes consisting of the principal alpha subunits (CNG1-3), which can form functional channels by themselves, and the modulatory beta subunits (CNG4-5). The individual alpha and beta subunits that combine to form the CNG channels in rod photoreceptors (CNG1 + CNG4)...

Journal: :The Journal of neuroscience : the official journal of the Society for Neuroscience 1997
E Molokanova B Trivedi A Savchenko R H Kramer

Cyclic nucleotide-gated (CNG) channels in vertebrate photoreceptors are crucial for transducing light-induced changes in cGMP concentration into electrical signals. In this study, we show that both native and exogenously expressed CNG channels from rods are modulated by tyrosine phosphorylation. The cGMP sensitivity of CNG channels, composed of rod alpha-subunits expressed in Xenopus oocytes, g...

Journal: :Neuron 1994
E R Liman L B Buck

Sensory transduction in olfactory neurons is mediated by intracellular cAMP, which directly gates a nonselective cation channel. A cDNA encoding a cyclic nucleotide-gated (CNG) ion channel subunit (rOCNC1) has been cloned previously from rat olfactory epithelium. However, differences between the functional properties of rOCNC1 and the native olfactory CNG channel suggest that the native channel...

2013
M. M. Gosal Gajendra Babu

Experimental investigations carried out on a single-cylinder four-stroke motorcycle spark ignition engine operating on gasoline and natural gas are reported in the present paper when compressed natural gas (CNG) and hydrogen were used as fuel. The investigations were carried out by mixing a small percentage of hydrogen (5 to 30%) with CNG and supplied to the engine. Hydrogen and CNG were mixed ...

Journal: :The Journal of biological chemistry 1997
T Misaka Y Kusakabe Y Emori T Gonoi S Arai K Abe

Cyclic nucleotide-gated (CNG) channels have been characterized as important factors involved in physiological processes including sensory reception for vision and olfaction. The possibility thus exists that a certain CNG channel functions in gustation as well. In the present study, we carried out reverse transcription-polymerase chain reaction and genomic DNA cloning and characterized a CNG cha...

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