The minichromosome maintenance (MCM) proteins are highly conserved proteins essential for initiating and regulating eukaryotic DNA replication. Recent studies have demonstrated the potential use of MCM proteins as markers of proliferation. We characterized the pattern of Mcm 2 staining in benign and malignant prostate tissues and examined the role of Mcm 2 expression in disease-free survival af...

سن گلخوار یونجه، Lygus rugulipennis Poppius (Hemiptera: Miridae)، یکی از آفات مهم یونجه در بسیاری نقاط جهان می‌باشد. زیست‌شناسی آزمایشگاهی و پراسنجه‌های جدول زندگی این آفت پنج دمای 25، 5/27، 30، 5/32 35 درجه سلسیوس، رطوبت نسبی 5 ±60 درصد دوره نوری 16 ساعت روشنایی 8 تاریکی مورد بررسی قرار گرفت. قادر به نشوونما سلسیوس نبود. طولانی‌ترین کوتاه‌ترین طول پورگی به‌ترتیب 5/27 (81/13 روز) (08/8 به‌دست آ...

The minichromosome maintenance (MCM) proteins MCM2-MCM7 are conserved eukaryotic replication factors that assemble in a heterohexameric complex. In fission yeast, these proteins are nuclear throughout the cell cycle. In studying the mechanism that regulates assembly of the MCM complex, we analyzed the cis and trans elements required for nuclear localization of a single subunit, Mcm2p. Mutation ...

Ecofriendly chitosan/Al-MCM-48 (CH/Al-MCM) was synthesized from natural microcline and assessed as a potential adsorbent of As (V) ions with enhanced capacity. The adsorption properties CH/Al-MCM were in comparison Al-MCM-41 single phase. studied exhibits 178.6 mg/g capacity which is higher than (124 mg/g). illustrated based on the pseudo-first-order kinetic, Langmuir isotherm, monolayer model ...

5. Regulation of MCM proteins during the cell cycle . . . . . . . . . . . . . . . . . . . . . . . . . . . . 125 5.1. MCM protein levels in proliferating and non-proliferating cells . . . . . . . . . . . . . . . . . 125 5.2. Involvement of ORC and Cdc6rcdc18 in binding of MCM proteins to chromatin . . . . . . 126 5.3. Role of phosphorylation in regulating MCM function . . . . . . . . . . . . . ....

Origins of DNA replication are licensed by recruiting MCM2-7 to assemble the prereplicative complex (pre-RC). How MCM2-7 is inactivated or removed from chromatin at the end of S phase is still unclear. Here, we show that MCM-BP can disassemble the MCM2-7 complex and might function as an unloader of MCM2-7 from chromatin. In Xenopus egg extracts, MCM-BP exists in a stable complex with MCM7, but ...

The members of the MCM protein family are essential eukaryotic DNA replication factors that form a six-member protein complex. In this study, we use antibodies to four MCM proteins to investigate the structure of and requirements for the formation of fission yeast MCM complexes in vivo, with particular regard to Cdc19p (MCM2). Gel filtration analysis shows that the MCM protein complexes are uns...

MCM-41 based catalysts (molar ratio Si/Al = 40) were prepared by a hydrothermal route, modified ionic exchange with different metals (Cu, Cr, Fe and Zn) finally calcined at 550 °C. The fully characterized techniques that confirmed the formation of oxides on surfaces all materials. Low-angle X-ray diffraction (XRD) analyses showed calcination resulted in incorporation metallic Zn, Cr framework M...

The minichromosome maintenance (MCM) complex is a replicative helicase, which is essential for chromosome DNA replication. In recent years, the identification of a novel MCM-binding protein (MCM-BP) in most eukaryotes has led to numerous studies investigating its function and its relationship to the MCM complex. However, the mechanisms by which MCM-BP functions and associates with MCM complexes...