The variant form of acute promyelocytic leukaemia (AML-M3) possesses its own characteristic morphology, although usually a few of the cells may have cytoplasmic features of typical AML-M3. In contrast to typical AML-M3, this M3-variant form commonly presents with hyperleucocytosis. As in typical AML-M3, disseminated intravascular coagulopathy (DIVC) occurs in the M3-variant. A boy with this mor...

Chemokines are involved in recruitment and activation of hematopoietic cells in sites of infection and inflammation. The M3 gene of the gamma-herpesvirus gammaHV68 encodes an abundant secreted protein that binds CC chemokines with high affinity. We report here that this gene is essential for efficient induction of lethal meningitis by gammaHV68. An M3 mutant gammaHV68 (gammaHV68-M3.stop) was 10...

α1 α2 α3 α4 inModR. If the rows are exact, then the following statements hold. (1.3.a) If γ2 and γ4 are injective and γ1 is surjective, then γ3 is injective. (1.3.b) If γ2 and γ4 are surjective and γ5 is injective, then γ3 is surjective. Proof. First we prove (1.3.a). So suppose that γ2 and γ4 are injective and γ1 is surjective. Start with m3 ∈ M3 with the property that γ3(m3) = 0. The goal is ...

We used a new monoclonal antibody (mAb 130) to analyze the intracellular trafficking and surface expression of H2-M3, the major histocompatibility complex class Ib molecule that presents N-formylated peptides to cytotoxic T cells. M3 surface expression is undetectable in most cell types due to the paucity of endogenous antigen. M3 is induced on the cell surface by addition of high-affinity N-fo...

Negative chronotropic and smooth muscle contractile responses to the nonselective muscarinic agonist carbamylcholine were compared in isolated tissues from M3 muscarinic receptor knockout and wild-type mice. Carbamylcholine (10-3.0x10M) induced a concentration-dependent decrease in atrial rate that was similar in atria from M3 receptor knockout and wild-type mice, indicating that M3 receptors w...

The maximum permissible concentration (MPC) of chloroprene was set at 2 mg/m3 in the USSR in the 1940's. The existing MPC is 4 mg/m3. The threshold of systemic effects as a result of chronic chloroprene exposure is l.69 mg/m3. However, the threshold for embryotoxic and mutagenic effects is 0.15 mg/m3. In consideration of this information, setting a new MPC for chloroprene at 0.05 mg/m3 is reco...