Network Mobility Basic Support Protocol (NEMO BSP) is considered as the most widespread network mobility protocol at the present time which is a logical extension of the MIPv6 operation. Hence, Location Update (LU) procedure of NEMO BSP is almost similar to MIPv6 registration apart from setting of the MR flag and sending of prefix in the Binding Update (BU). However, in NEMO network, providing ...

Somatic mosaicism has been described in several primary immunodeficiency diseases and causes modified phenotypes in affected patients. X-linked anhidrotic ectodermal dysplasia with immunodeficiency (XL-EDA-ID) is caused by hypomorphic mutations in the NF-κB essential modulator (NEMO) gene and manifests clinically in various ways. We have previously reported a case of XL-EDA-ID with somatic mosa...

In an effort to provide a solution to the problem of internetworking mountain rescue workers without the use of a fixed infrastructure, our group has explored the use of a network model based on the concept of Network Mobility and the use of the NEMO Basic Support Protocol. In this paper we consider the feasibility of this approach through the design, configuration and testing of a working exam...

Intestinal epithelial cells (IECs) regulate gut immune homeostasis, and impaired epithelial responses are implicated in the pathogenesis of inflammatory bowel diseases (IBD). IEC-specific ablation of nuclear factor κB (NF-κB) essential modulator (NEMO) caused Paneth cell apoptosis and impaired antimicrobial factor expression in the ileum, as well as colonocyte apoptosis and microbiota-driven ch...

Activation of nuclear factor-kappaB (NF-kappaB), a key mediator of inducible transcription in immunity, requires binding of NF-kappaB essential modulator (NEMO) to ubiquitinated substrates. Here, we report that the UBAN (ubiquitin binding in ABIN and NEMO) motif of NEMO selectively binds linear (head-to-tail) ubiquitin chains. Crystal structures of the UBAN motif revealed a parallel coiled-coil...

With Network Mobility Basic Support Protocol (NEMO BSP), each communication should pass via the home agents of all mobile routers earlier reaching their destination at the time of frequent movement among the inter-technology handoff. This eventually results in performance deterioration of the real time application scenarios conducted on mobile nodes. Accordingly, applying the multihoming techni...

In this paper, we propose a Network-based NEtwork MObility supporting scheme (N-NEMO) in Proxy Mobile IPv6 (PMIPv6) network, which is an issue still up in the air for the basic PMIPv6 protocol. The N-NEMO, like PMIPv6, bases mobility support on network functionality, thus enabling conventional (i.e., not mobility-enabled) IP devices to change their point of attachment without disrupting ongoing...

Transcription factor NF-kappaB controls the expression of multiple genes involved in immunity and inflammation. The initial activation and duration of NF-kappaB signaling is regulated by posttranslational modifications to IkappaB kinase, which earmarks inhibitors of NF-kappaB for degradation. Prior studies suggest that K63-linked ubiquitination of NEMO (NF-kappaB essential modulator), an Ikappa...

The mobile networks play a vital role in the information and communication technology. There are two kinds of mobility supported by mobile networks such as host mobility and network mobility. The enhancement of Quality of Service (QoS) in NEtwork MObility (NEMO) environment is more complex than host mobility environment. One of the complexities in NEMO environment is routing of packets. The rou...

IκB kinase/nuclear [corrected] factor κB (IKK/NF-κB) signaling exhibits important yet opposing functions in hepatocarcinogenesis. Mice lacking NEMO in liver parenchymal cells (LPC) spontaneously develop steatohepatitis and hepatocellular carcinoma (HCC) suggesting that NF-κB prevents liver disease and cancer. Here, we show that complete NF-κB inhibition by combined LPC-specific ablation of RelA...