RNA interference (RNAi) represents a high effective mechanism for specific inhibition of mRNA expression. Besides its potential as a powerful laboratory tool, the RNAi pathway appears to be promising for therapeutic utilization. For development of RNA interference (RNAi)-based therapies, delivery of RNAi-mediating agents to target cells is one of the major obstacles. A novel strategy to overcom...

Insects and ectoparasites are causes for major concern throughout the world due to their economic welfare impacts on livestock agriculture. Current control measures involve chemicals such as acaricides which pose challenges like chemical resistance longer withholding periods. To enable more sustainable agriculture practices, it is important develop technologies that combine targeted effectivene...

Abstract When stress factors trigger transcriptional and metabolic changes, RNA interference (RNAi) is associated with gene expression regulation at the post-transcriptional levels. RDR, DCL AGO proteins contribute to these silencing processes during reactions plant development. An entire revision of maize genes was carried out prior experiments. In this study, transcript changes a total 4 ZmRD...

The Effect of Chalcone Isomerase (Chi) Gene Silencing on Flavonoids Content in Petunia hybrida using RNAi Technology

RNA interference (RNAi) is a promising strategy to suppress the expression of disease-relevant genes and induce post-transcriptional gene silencing. Their simplicity and stability endow RNAi with great advantages in molecular medicine. Several RNAi-based drugs are in various stages of clinical investigation. This review summarizes the ongoing research endeavors on RNAi in molecular medicine, de...