BACKGROUND We describe the spectrum of etiologies associated with temporal lobe (TL) encephalitis and identify clinical and radiologic features that distinguish herpes simplex encephalitis (HSE) from its mimics. METHODS We reviewed all adult cases of encephalitis with TL abnormalities on magnetic resonance imaging (MRI) from the California Encephalitis Project. We evaluated the association be...

BACKGROUND The Health and Safety Executive (HSE) has defined six management standards representing aspects of work that, if poorly managed, are associated with lower levels of employee health and productivity, and increased sickness absence. The HSE indicator tool aims to measure organizations' performance in managing the primary stressors identified by the HSE management standards. AIMS The ...

Gas refineries have been continuously focusing on Health, Safety and Environment programs to improve maintenance activities. Several researches have studied on this area with different analysis methods. This study presents an integrated approach for optimization of factors contributing to the implementation of Health, Safety and Environment (HSE) in maintenance activities. HSE managers in each ...

This report was produced for the HSE project on 'Assessment of Software Components for use in IEC 61508-Compliant Safety-Related Applications'. The main focus for this project is 'software of uncertain pedigree' (SOUP) used in safety-related applications. This document reviews current assessment methods for SOUP and summarises the evidence required for their use according to IEC 61508 and other...

Herpes simplex encephalitis (HSE) is a life-threatening complication of herpes simplex virus (HSV) infection. Acyclovir (ACV) is the antiviral treatment of choice, but may lead to emergence of ACV-resistant (ACVR) HSV due to mutations in the viral UL23 gene encoding for the ACV-targeted thymidine kinase (TK) protein. Here, we determined the prevalence of intrathecal ACVR-associated HSV TK mutat...