BACKGROUND JM-1232(-) is a novel isoindoline derivative which shows sedative and hypnotic activities through the benzodiazepine site of gamma-aminobutyric acid type A (GABAA) receptors. Typical doses of midazolam, another GABAA receptor agonist, slightly reduce the shivering threshold in humans. We thus determined the extent to which JM-1232(-) decreases the shivering threshold. METHODS Eight...

We consider the job shop scheduling problem unit−Jm, where each job is processed once on each of m given machines. Every job consists of a permutation of tasks for all machines. The execution of any task on its corresponding machine takes exactly one time unit. The objective is to minimize the overall completion time, called makespan. The contribution of this paper are the following results: (i...

JM-20 (3-ethoxycarbonyl-2-methyl-4-(2-nitrophenyl)-4,11-dihydro-1H-pyrido[2,3-b][1,5]benzodiazepine) is a novel benzodiazepine dihydropyridine hybrid molecule, which has been shown to be a neuroprotective agent in brain disorders involving glutamate receptors. However, the effect of JM-20 on the functionality of the glutamatergic system has not been investigated. In this study, by using differe...

Despite not knowing the exact age of individuals, humans can estimate their rough age using age-related physical features. Nonhuman primates show some age-related physical features; however, the cognitive traits underlying their recognition of age class have not been revealed. Here, we tested the ability of two species of Old World monkey, Japanese macaques (JM) and Campbell's monkeys (CM), to ...

Activation of the protein tyrosine kinase receptors requires the coupling of ligand binding to a change in both the proximity and orientation of the single transmembrane (TM) helices of receptor monomers to allow transphosphorylation of the receptor kinase domain. We make use of peptides corresponding to the TM and juxtamembrane (JM) regions of the fibroblast growth factor receptor 3 to assess ...

s directly related to the thesis 1. Bodosi B, Gardi J, Hajdu I, Szentirmai É, Obál F Jr., Krueger JM. Ghrelin and leptin responses to sleep deprivation and to reversed feeding schedule in rats. J Sleep Res 13, S1, p. 83, 2004. 2. Gardi J, Bodosi B, Hajdu I, Szentirmai É, Obál F Jr., Krueger JM. Rhythms of ghrelin and leptin with respect to sleep and feeding in rats. J Sleep Res 13, S1, p. 259, ...

3 Shamberger RC, Grier HE, Weinstein JH, et al. Chest wall tumors in infancy and childhood. Cancer 1989; 63: 774-85. 4 Askin FB, Rosai J, Sibley RK, Dehner LP, McAlister WH. Malignant small cell tumor of the thoracopulmonary region in childhood: a distinctive clinicopathologic entity of uncertain histogenesis. Cancer 1979; 43: 2438-51. 5 Sabate JM, Franquet T, Parellada JM, Monill JM, Olive E. ...

Accurate segregation of homologous chromosomes of different parental origin (homologs) during the first division of meiosis (meiosis I) requires inter-homolog crossovers (COs). These are produced at the end of meiosis I prophase, when recombination intermediates that contain Holliday junctions (joint molecules, JMs) are resolved, predominantly as COs. JM resolution during the mitotic cell cycle...

Erythropoiesis is regulated by the erythropoietin receptor (EpoR) binding to its ligand. The transmembrane domain (TMD) and the juxtamembrane (JM) regions of the EpoR are important for signal transduction across the cell membrane. We report a solution NMR study of the mouse erythropoietin receptor (mEpoR) comprising the TMD and the JM regions reconstituted in dodecylphosphocholine (DPC) micelle...

Injective Pure Type Systems form a large class of Pure Type Systems for which one can compute by purely syntactic means two sorts elmt(?jM) and sort(?jM), where ? is a pseudo-context and M is a pseudo-term, and such that for every sort s, ? ` M : A ^ ? ` A : s) elmt(?jM) = s ? ` M : s) sort(?jM) = s By eliminating the problematic clause in the (abstraction) rule in favour of constraints over el...