The plant 4-HYDROXY-3-METHYLBUT-2-ENYL DIPHOSPHATE REDUCTASE (HDR) catalyzes the last step of the methylerythritol phosphate pathway to synthesize isopentenyl diphosphate and its allyl isomer dimethylallyl diphosphate, which are common precursors for the synthesis of plastid isoprenoids. The Arabidopsis (Arabidopsis thaliana) genomic HDR transgene-induced gene-silencing lines are albino, varieg...

Homology-directed repair (HDR) of DNA double-strand breaks (DSBs) contributes to the maintenance of genomic stability in rodent cells, and it has been assumed that HDR is of similar importance in DSB repair in human cells. However, some outcomes of homologous recombination can be deleterious, suggesting that factors exist to regulate HDR. We demonstrated previously that overexpression of BCL-2 ...

DNA nicks are the most common form of DNA damage, and if unrepaired can give rise to genomic instability. In human cells, nicks are efficiently repaired via the single-strand break repair pathway, but relatively little is known about the fate of nicks not processed by that pathway. Here we show that homology-directed repair (HDR) at nicks occurs via a mechanism distinct from HDR at double-stran...

High dynamic range (HDR) image generation and display technologies are becoming increasingly popular in various applications. A standard and commonly used approach to obtain an HDR image is the multiple exposures fusion technique which consists of combining multiple images of the same scene with varying exposure times. However, if the scene is not static during the sequence acquisition, moving ...

There are a number of modern myths about High Dynamic Range (HDR) imaging. There have been claims that multiple-exposure techniques can accurately record scene luminances over a dynamic range of more than a million to one. There are assertions that human appearance tracks the same range. The most common myth is that HDR imaging accurately records and reproduces actual scene radiances. Regardles...

This paper proposes the first end-to-end deep framework for high dynamic range (HDR) imaging of dynamic scenes with large-scale foreground motions. In state-of-the-art deep HDR imaging such as [13], the problem is formulated as an image composition problem, by first aligning input images using optical flows which are still error-prone due to occlusion and large motions. In our end-to-end approa...

High Dynamic Range (HDR) imaging is one of the technologies that are changing photo, TV, and film industries. The popularity and full public adoption of HDR content is however hindered by the lack of standards in evaluation of quality, file formats, and compression, as well as large legacy base of Low Dynamic Range (LDR) displays that are unable to render HDR. Many tone-mapping operators, aimin...

Treatment of cervical cancer includes combination of external beam radiation therapy (EBRT) and brachytherapy (BRT). Traditionally, coronal images displaying dose distribution from a ring and tandem (R&T) implant aid in construction of parametrial boost fields. This research aimed to evaluate a method of shaping parametrial fields utilizing contours created from the high-dose-rate (HDR) BRT dos...