2. The glucosyl, maltosyl and lactosyl derivatives of 6-APA were prepared as their sodium salts and some of their properties examined. 3. These derivatives of 6-APA are stable to both staphylococcal and Bacillua cereus penicillinase, but are readily hydrolysed to the parent compounds by acid. 4. Compounds behaving like those prepared from 6-APA and sugars were identified in both the culture fil...

This study was undertaken to explore whether intervention with heparin and aspirin (H/A) in selected patients undergoing in-vitro fertilization (IVF) and embryo transfer could improve fecundity rates. Specifically, it explored the possibility that women diagnosed with organic pelvic disease who demonstrated antiphospholipid antibodies (APA) could benefit from H/A administration in a similar man...

Wild-type Escherichia coli cells became spherical in the presence of low concentrations of 6-aminopenicillanic acid (APA). Higher concentrations of APA caused inhibition of cell division (filamentation) and lysis. Spontaneous temperature-sensitive APA-resistant mutants were isolated and characterized. These mutants also possessed increased resistance to mecillinam but not to benzylpenicillin, a...

Alternative polyadenylation (APA), a phenomenon that RNA molecules with different 3' ends originate from distinct polyadenylation sites of a single gene, is emerging as a mechanism widely used to regulate gene expression. In the present review, we first summarized various methods prevalently adopted in APA study, mainly focused on the next-generation sequencing (NGS)-based techniques specially ...

Delay in the Diagnosis of Conn’s Syndrome: A Single-Center Experience Over 30 Years To the Editor: The study reported by Rossi et al1 addressed predictors of outcome in aldosterone-producing adenoma (APA) patients postadrenalectomy. The time-dependent process of adverse vascular remodeling, determined by an increased media/lumen ratio of resistance arteries, was hypothesized to predict a poorer...

Aminopeptidase A (APA) cleaves the N-terminal aspartyl acid residue of angiotensin II (Ang II) to produce angiotensin III (Ang III). It has been reported that the APA knockout mouse exhibits elevated blood pressure. Therefore, the APA gene is thought to be a susceptibility gene for essential hypertension (EH). However, extensive studies have yet to define the relationship between the APA gene a...

OBJECTIVE To use a new immunologic assay to evaluate antipolymer antibody (APA) levels among women with silicone breast implants (SBIs). METHODS Women (n = 186) were identified through Danish population-based registers and categorized into six groups defined by prior breast surgery (silicone breast implantation/breast reduction/no breast surgery) and by the presence or absence of a prior hosp...

mRNA alternative polyadenylation (APA) plays a critical role in post-transcriptional gene control and is highly regulated during development and disease. However, the regulatory mechanisms and functional consequences of APA remain poorly understood. Here, we show that an mRNA 3' processing factor, Fip1, is essential for embryonic stem cell (ESC) self-renewal and somatic cell reprogramming. Fip1...

The clinical significance of anti-pituitary antibodies (APA) was examined by enzyme-linked immunosorbent assay (ELISA) in individuals with non-insulin dependent diabetes mellitus (NIDDM). Serum samples were obtained from 150 NIDDM patients and 45 normal subjects. Urinary C-peptide (UCPR) was also measured for the NIDDM patients. APA-positive serum was incubated with porcine pancreas, liver, kid...