The "therapeutic chelation" approach to treating Alzheimer's disease (AD) evolved from the metals hypothesis, with the premise that small molecules can be designed to prevent transition metal-induced amyloid deposition and oxidative stress within the AD brain. Over more than 20 years, countless in vitro studies have been devoted to characterizing metal binding, its effect on Aβ aggregation, ROS...

Trial to Assess Chelation Therapy (TACT) was a prospective, randomized, double-blind, placebo-controlled trial designed to evaluate the effect of ethylenediaminetetraacetic acid-based intravenous chelation therapy on cardiovascular outcomes. A total of 1708 stable patients >50 years of age with a previous myocardial infarction were enrolled at 134 North American sites and followed for a median ...

Goldschmidt, Millicent C. (University of Texas, Austin), and Orville Wyss. Chelation effects on Azotobacter cells and cysts. J. Bacteriol. 91:120-124. 1966.-Ethylenediaminetetraacetate (EDTA) is very toxic to Azotobacter in the presence of nitrogen compounds that form complexes with it. This appears to be due to stronger chelation of certain metal ions by the complex. When such complexes of EDT...

In this case presentation, a woman with high serum levels of aluminum was treated with chelation therapy with deferoxamine and ascorbic acid. This patient was initially bedridden and the clinical situation was complicated by epileptic seizures. After the chelation therapy, the clinical condition was ameliorated and the therapy continued without the correlation to aluminum serum levels. The role...

Regular blood transfusion along with iron chelation therapy is a supportive treatment for thalassemia major. Chelation therapy too has its side effects. The most common adverse effects associated with administration of deferiprone are agranulocytosis, neutropenia and arthralgia, primarily, of the large joints. Objective : The study was undertaken to examine the effect of deferiprone on the larg...