Mutations in three subunits of the SWI/SNF complex and in the Med2p subunit of the SRB/mediator of pol II holoenzyme impaired Gcn4p-activated transcription of HIS3 without reducing Gcn4p-independent transcription of this gene. Recombinant Gcn4p interacted with SWI/SNF and SRB/mediator subunits in cell extracts in a manner dependent on the same hydrophobic clusters in the Gcn4p activation domain...

BACKGROUND Susceptibility weighted imaging (SWI) is a velocity compensated, high-resolution three-dimensional (3D) spoiled gradient-echo sequence that uses magnitude and filtered-phase data. SWI seems to be a valuable tool for non-invasive evaluation of central nervous system gliomas. Relative cerebral blood volume (rCBV) ratio is one of the best noninvasive methods for glioma grading. Degree o...

background: to analyze the characteristic performance of magnetic resonance spectroscopy (mrs) and susceptibility weighted imaging (swi) in cerebral alve-olar echinococcosis (cae). methods: we retrospectively analyzed 10 clinical-identified cae cases mr per-formance, and summarized the mrs and swi performance of cae. results: the 10 cases of cae all had the history of primary hae, among who 6 c...

Introduction Susceptibility Weighted Imaging (SWI) method is commonly used for Magnetic Resonance (MR) venography. The difference between SWI and conventional GRE imaging is that phase information of signal is incorporated to enhance contrast of image. The phase can provide excellent contrast between venous blood vessels and other tissues with susceptibilities that are different from the backgr...

The yeast SWI/SNF complex is the prototype of a subfamily of ATP-dependent chromatin remodeling complexes. It consists of eleven stoichiometric subunits including Swi2p/Snf2p, Swi1p, Snf5p, Swi3p, Swp82p, Swp73p, Arp7p, Arp9p, Snf6p, Snf11p, and Swp29p, with a molecular weight of 1.14 mega Daltons. Swi2p/Snf2p, the catalytic subunit of SWI/SNF, is evolutionally conserved from yeast to human cel...

There is a close relationship between histone acetylation and ATP-dependent chromatin remodeling that is not fully understood. We show that acetylation of histone H3 tails affects SWI/SNF (mating type switching/ sucrose non fermenting) and RSC (remodels structure of chromatin) remodeling in several distinct ways. Acetylation of the histone H3 N-terminal tail facilitated recruitment and nucleoso...

SWI/SNF is an ATP-dependent remodeler that mobilizes nucleosomes and has important roles in gene regulation. The catalytic subunit of SWI/SNF has an ATP-dependent DNA translocase domain that is essential for remodeling. Besides the DNA translocase domain there are other domains in the catalytic subunit of SWI/SNF that have important roles in mobilizing nucleosomes. One of these domains, termed ...

Saltwater intrusion (SWI) is a type of pollution that adversely affects the quality groundwater in coastal aquifers. The Nile Delta aquifer (NDA) Egypt contains large amount freshwater. Increasing abstraction from and sea level rise have led to an increase SWI, which has reached up 100 km inland. Therefore, practical measures are required prevent further SWI. This study aims identify optimal we...

To evaluate malignant middle cerebral artery (MCA) infarction (defined as space-occupying edema in more than 50% to 75% of the MCA territory) on magnetic resonance imaging (MRI) with susceptibility-weighted imaging (SWI) sequence and assess the usefulness of SWI findings, diffusion-weighted imaging (DWI) findings, and apparent diffusion coefficient (ADC) as predictors of clinical outcome.Data f...