نتایج جستجو برای: شاخص ed50

تعداد نتایج: 76082  

2017
Mingyang Shi Guangbo Xie Xiaoshuai Fan Weidong Pan Xiaoshuang Zhou Jingbo Yuan Zeyi Chen Guo Chen

Background: Systemic administration of local anesthetics can produce systemic actions, but the details of these actions and mechanisms are still unclear. We evaluated the systemic actions of three local anesthetics and their underlying mechanisms in this study. Methods: Lidocaine, bupivacaine and ropivacaine were injected into C57BL/6 mice through tail vein, alone or together with hyperpolariza...

2014
Michael Salmon Stacey L Tannheimer Terry T Gentzler Zhi-Hua Cui Eric A Sorensen Kimberly C Hartsough Musong Kim Lafe J Purvis Edward G Barrett Jacob D McDonald Karin Rudolph Melanie Doyle-Eisele Philip J Kuehl Christopher M Royer William R Baker Gary B Phillips Clifford D Wright

Bronchodilators are a central therapy for symptom relief in respiratory diseases such as chronic obstructive pulmonary disease (COPD) and asthma, with inhaled β 2-adrenoceptor agonists and anticholinergics being the primary treatments available. The present studies evaluated the in vivo pharmacology of (R)-6-[[3-[[4-[5-[[2-Hydroxy-2-(8-hydroxy-2-oxo-1,2-dihydroquinolin-5-yl)ethyl]amino]pent-1-y...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 2014
Yizhou Dong Kevin T Love J Robert Dorkin Sasilada Sirirungruang Yunlong Zhang Delai Chen Roman L Bogorad Hao Yin Yi Chen Arturo J Vegas Christopher A Alabi Gaurav Sahay Karsten T Olejnik Weiheng Wang Avi Schroeder Abigail K R Lytton-Jean Daniel J Siegwart Akin Akinc Carmen Barnes Scott A Barros Mary Carioto Kevin Fitzgerald Julia Hettinger Varun Kumar Tatiana I Novobrantseva June Qin William Querbes Victor Koteliansky Robert Langer Daniel G Anderson

siRNA therapeutics have promise for the treatment of a wide range of genetic disorders. Motivated by lipoproteins, we report lipopeptide nanoparticles as potent and selective siRNA carriers with a wide therapeutic index. Lead material cKK-E12 showed potent silencing effects in mice (ED50 ∼ 0.002 mg/kg), rats (ED50 < 0.01 mg/kg), and nonhuman primates (over 95% silencing at 0.3 mg/kg). Apolipopr...

Journal: :British journal of anaesthesia 1990
I Ben-Shlomo H abd-el-Khalim J Ezry S Zohar M Tverskoy

The induction dose-response of midazolam was compared with the dose-response of its combination with fentanyl and with that of fentanyl alone in three groups of 60 unpremedicated, ASA physical status I or II women undergoing minor gynaecological surgery. The end-point of induction of anaesthesia was inability to open eyes upon command. Dose-response curves were determined for each group with a ...

Journal: :The Journal of Cell Biology 1987
K Hanai H Kato S Matsuhashi H Morita E W Raines R Ross

Human serum more strongly depressed the feeding response of Hydra (ball formation) elicited by S-methylglutathione than plasma. On the basis of the effect of several proteins released by platelets, at least five apparent components of the response (R1-R5) were suggested. Each of the platelet proteins examined specifically depressed a subset of these components. Among the platelet proteins exami...

Journal: :Journal of lipid research 1981
E M Dax J S Partilla R I Gregerman

beta-adrenergic binding ([3H]dihydroalprenolol), adenylate cyclase activity, and cAMP accumulation were measured in adipocytes to investigate whether the mechanism of decreased hormone-sensitive lipolytic response with age was mediated through membrane-associated events. The dose of epinephrine required for half maximal stimulation of glycerol release (ED50) was significantly lower in 2-month-o...

Journal: :Planta medica 2016
José Clementino-Neto Joedna C Pereira Luiz H C Vasconcelos Iara L L de Souza Anne D S Silva Telma M G Silva Natalia S M Ramos Hilzeth L F Pessôa Tania M S Silva Bagnólia A da Silva Fabiana A de Cavalcante

Solanum paniculatum is popularly known as "jurubeba-verdadeira". In folk medicine, its roots, stems, and leaves are used as tonics, anti-inflammatories, carminatives, diuretics, and for gastrointestinal disorders. This species is listed in the Brazilian Pharmacopoeia and belongs to the "Relação Nacional de Plantas Medicinais de Interesse ao SUS". Based on folk medicine data of the Solanum genus...

Journal: :Molecules 2014
Adeleke Clement Adebajo Samuel Akintunde Odediran Fatimah Abosede Aliyu Paul Alozie Nwafor Ndifreke Thomas Nwoko Usenobong Samuel Umana

Various combinations of Nauclea latifolia root, Artocarpus altilis stem bark, Murraya koenigii leaf and Enantia chlorantha stem bark used in African ethnomedicine as decoctions for malaria and fevers, and combinations with standard drugs, were investigated for antiplasmodial activities using Plasmodium berghei berghei-infected mice. The respective prophylactic and curative ED50 values of 189.4 ...

Journal: :The Journal of pharmacology and experimental therapeutics 1997
S M Thacher A M Standeven J Athanikar S Kopper O Castilleja M Escobar R L Beard R A Chandraratna

Retinoid induction of epidermal hyperplasia was investigated in hairless mice with synthetic ligands for the retinoic acid (RAR) and retinoid X (RXR) nuclear receptors. Induction of hyperplasia by all-trans retinoic acid and the RAR-specific retinoids TTNPB, tazarotene and AGN 190121 varied over a wide range (ED50 = 0.2-100 nmol/animal in three daily applications). Potency of induction was not ...

Journal: :Chemical & pharmaceutical bulletin 2003
Tadashi Ogawa Mamoru Araki Tetsuhisa Miyamae Toru Okayama Masaki Hagiwara Shinobu Sakurada Tadanori Morikawa

To improve the oral bioavailability of a dermorphin tetrapeptide analog, N(alpha)-1-iminoethyl-Tyr-D-MetO-Phe-MebetaAla-OH (III), which has a potent analgesic activity after oral administration, various derivatives were synthesized to increase lipophilicity by esterification of the C-terminal carboxyl group and/or acylation of the phenolic hydroxyl group on Tyr1. Antinociceptive activity was ev...

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