Apolipoprotein A-IV (apoA-IV) is involved in the metabolism of chylomicrons and high density lipoproteins. It displays genetic polymorphism due to two co-dominant alleles apoA-IV1 and apoA-IV2. The mutation that causes the polymorphism is a G to T substitution in the third base of codon 360 in the apoA-IV2 allele which results in a glutamine (Gln) to histidine (His) change of amino acid 360. Th...

1.1. Constructions. To get from R to C, we can tensor with C. In a more coordinate-free manner, if W is an R-vector space, then its complexification WC := W ⊗R C is a C-vector space. We can view W as an R-subspace of WC by identifying each w ∈ W with w⊗ 1 ∈ WC. Then an R-basis of W is also a C-basis of WC. In particular, WC has the same dimension as W (but is a vector space over a different fie...

Human apolipoprotein (apo) A-IV is a polymorphic plasma protein controlled by two codominant alleles at a single genetic locus. Thus far, five different isoproteins (apoA-IV-O to apoA-N-4) have been described in Caucasians. We have recently identified the nucleotide and amino acid substitutions that are the basis for the most common isoproteins, apoA-IV-l and apoA-IV-2. In this report, the muta...

We consider a generalized version of the Steiner problem in graphs, motivated by the wire routing phase in physical VLSI design: given a connected, undirected distance graph with required classes of vertices and Steiner vertices, find a shortest connected subgraph containing at least one vertex of each required class. We show that this problem is NP-hard, even if there are no Steiner vertices a...

SIGNIFICANT clinical improvement after valvuloplasty for mitral stenosis can be anticipated in 70 per cent of group III patients followed 5 years and 52 per cent of those in group IV1 Nevertheless, the first 1,000 patients in our series have been followed from 2 to 9 years, and some degree of deterioration after an initially favorable result was found in 228. Critical scrutiny of the factors in...

SIGNIFICANT clinical improvement after valvuloplasty for mitral stenosis can be anticipated in 70 per cent of group III patients followed 5 years and 52 per cent of those in group IV1 Nevertheless, the first 1,000 patients in our series have been followed from 2 to 9 years, and some degree of deterioration after an initially favorable result was found in 228. Critical scrutiny of the factors in...

Molecular studies of nucleotide sequence variation have rarely attempted to test hypotheses related to geographically varying patterns of natural selection. The present study tested the role of spatially varying selection in producing significant linkage disequilibrium and large differences in the frequencies of two common alleles at the pantophysin (Pan I) locus among five populations of the A...

SIGNIFICANT clinical improvement after valvuloplasty for mitral stenosis can be anticipated in 70 per cent of group III patients followed 5 years and 52 per cent of those in group IV1 Nevertheless, the first 1,000 patients in our series have been followed from 2 to 9 years, and some degree of deterioration after an initially favorable result was found in 228. Critical scrutiny of the factors in...

1 Sellers WFS. Inhaled and intravenous treatment in acute severe and life-threatening asthma. Br J Anaesth 2013; 110: 183–90 2 Patel A, Harrison E, Durward A, et al. Intratracheal recombinant human deoxyribonuclease in acute life-threatening asthma refractory to conventional treatment. Br J Anaesth 2000; 84: 505–7 3 Durward A, Forte V, Shemie SD. Resolution of mucus plugging and atelectasis aft...