PURPOSE The stepping pictorial format of the Children's OMNI Perceived Exertion Scale (0-10) was validated for female (N = 20) and male (N = 20) children, 8-12 yr old with a peak (step) oxygen consumption of 46.1 +/- 5.3 mL.kg(-1).min(-1). METHODS Ratings of perceived exertion for the overall body (RPE-O), legs (RPE-L), and chest (RPE-C) were determined by the OMNI-Step Scale. Concurrent scal...

Age-related macular degeneration (AMD) is a devastating neurodegenerative disease and a major cause of blindness in the developed world. Owing to its complexity and the lack of an adequate human model that recapitulates key aspects of the disease, the molecular mechanisms of AMD pathogenesis remain poorly understood. Here we show that cultured human retinal pigment epithelium (RPE) from AMD don...

PURPOSE Retinal pigment epithelium (RPE) autologous grafts can be readily derived from induced pluripotent stem (iPS) cells. It is critical to stringently characterize iPS-RPE using standardized and quantifiable methods to be confident that they are safe and adequate replacements for diseased RPE before utilizing them in clinical settings. One important and required function is that the iPS-RPE...

هدف: هدف از پژوهش حاضر مقایسۀ واکنش ­پذیری هیجانی و نظریه ذهن کودکان بر اساس سبک ­های ابرازگری مادرانشان بود. روش: روش توصیفی نوع علّی-مقایسه­ ای بود در دو گام به صورت آنلاین انجام رسید. ابتدا با استفاده نمونه ­گیری دسترس، تعداد 105 نفر مادرانی که نمرات آن­ها هر یک پرسشنامه کینگ امونز (1990)، دوسوگرایی (1990) کنترل راجر نشوور (1987) انحراف استاندارد بالاتر میانگین دست آمد (در گروه 35 نفر) دوم وا...

Retinal pigment epithelial (RPE) cells in the back of the eye nourish photoreceptor cells and form a selective barrier that influences drug transport from the blood to the photoreceptor cells. At the molecular level, ATP-dependent efflux transporters have a major role in drug delivery in human RPE. In this study, we assessed the relative expression of several ATP-dependent efflux transporter ge...

UNLABELLED The criterion variables were total weight lifted (Wttot ) determined separately for women and men during BC and KE, and blood lactic acid concentration ([Hla]) determined for a combined female ( N = 10) and male ( N = 10) subset during BC. Subjects performed three separate sets of 4, 8, and 12 repetitions for BC and KE at 65% one-repetition maximum. Rating of perceived exertion for t...

Retinal pigment epithelium (RPE) transplantation is a particularly promising treatment of retinal degenerative diseases affecting RPE-photoreceptor complex. Embryonic stem cells (ESCs) provide an abundant donor source for RPE transplantation. Herein, we studied the time-course characteristics of RPE cells derived from three-dimensional human ESCs cultures (3D-RPE). We showed that 3D-RPE cells p...

I took great interest in the recent article regarding the retinal pigment epithelium (RPE) transplantation by Falkner-Radler et al. I agree that RPE cell transplantation might be a novel therapeutic option for patients in the antivascular endothelial growth factor (anti-VEGF) era, where antiVEGF fails to improve visual acuity. This is the case in RPE tear, massive subretinal haemorrhage or anti...

PURPOSE To describe, illustrate, and account for two cell types plausibly derived from RPE in geographic atrophy (GA) and choroidal neovascularization (CNV) of AMD, using melanosomes, lipofuscin, and basal laminar deposit (BLamD) as anatomical markers. METHODS Human donor eyes with GA (n = 13) or CNV (n = 39) were histologically processed, photodocumented, and analyzed for frequencies of occu...